Spirobisnaphthalenes from Fungi and their Biological Activities

被引：69
作者：
Zhou, L. [1 ]
Zhao, J. [1 ]
Shan, T. [1 ]
Cai, X. [1 ]
Peng, Y. [1 ]
机构：
[1] China Agr Univ, Dept Plant Pathol, Coll Agron & Biotechnol, Beijing 100193, Peoples R China
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2010年 / 10卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Spirobisnaphthalenes; spiroxin; preussomerin; deoxypreussomerin; fungi; biological activities; 1,8-DIHYDROXYNAPHTHALENE-DERIVED NATURAL-PRODUCTS; CRYSTAL-STRUCTURE ANALYSIS; ABSOLUTE-CONFIGURATION; CLADOSPIRONE BISEPOXIDE; ENDOPHYTIC FUNGUS; SECONDARY METABOLITES; ACTIVE METABOLITES; PALMARUMYCIN CP1; NAPHTHOQUINONE SPIROKETAL; ANTIFUNGAL METABOLITES;
D O I：
10.2174/138955710792007178
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Spirobisnaphthalenes have a unique structural feature involving two or three oxygen atoms acting as bridges connecting two original naphthalene subunits. Most of these metabolites isolated from fungi exhibit significant antifungal, antibacterial and cytotoxic properties to show great potential applications in medicine and agriculture. This review focuses on their structural characters and biological activities, as well as their structure-activity relationship, mechanism of action, synthesis and biosynthesis.
引用
收藏
页码：977 / 989
页数：13
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