Water solubility is essential for fluorescent probes to image hypochlorous acid in live cells

被引：35
|
作者：
Xing, Panfei [1 ]
Zhang, Zhe [1 ]
Niu, Yiming [1 ]
Qi, Yaning [2 ]
Dong, Lei [3 ]
Wang, Chunming [1 ]
机构：
[1] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa, Macau, Peoples R China
[2] Univ Macau, Choi Kai Yau Coll, Taipa, Macau, Peoples R China
[3] Nanjing Univ Inst, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 71期
关键词：
BIOIMAGING APPLICATIONS; SELECTIVE DETECTION; RECENT PROGRESS; LIVING CELLS; IN-VIVO; OXIDATION; LYSOSOME; HOCL; MITOCHONDRIA; STRESS;
D O I：
10.1039/c8cc04631j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We synthesised four probes and compared their HClO-detecting ability in different solvents. The data showed that only hydrophilic probes could sensitively and accurately detect HClO in live cells. Meanwhile, the addition of organic solvents, as is commonly practised, weakens the oxidising capacity of HClO and thus generates inaccurate outcomes.
引用
收藏
页码：9889 / 9892
页数：5
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