Regeneration-Related Functional Cargoes in Mesenchymal Stem Cell-Derived Small Extracellular Vesicles

被引：8
|
作者：
Zhu, Zhongyi [1 ,2 ]
Zhang, Yijing [1 ,2 ,3 ]
Wu, Ligang [4 ,5 ]
Hua, Keqin [1 ,2 ]
Ding, Jingxin [1 ,2 ]
机构：
[1] Fudan Univ, Obstet & Gynecol Hosp, Dept Gynecol, Shanghai, Peoples R China
[2] Shanghai Key Lab Female Reprod Endocrine Related, Shanghai, Peoples R China
[3] Shanghai Ji Ai Genet & IVF Inst, Shanghai, Peoples R China
[4] Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, State Key Lab Mol Biol, Shanghai, Peoples R China
[5] Univ Chinese Acad Sci, Shanghai, Peoples R China
来源：
STEM CELLS AND DEVELOPMENT | 2020年 / 29卷 / 01期
关键词：
stem cell; regeneration; small extracellular vesicle; microRNA; lncRNA; protein; STROMAL CELLS; IN-VITRO; EXOSOMES; MICRORNAS; INJURY; DIFFERENTIATION; ENHANCE; REPAIR; MODULATION; CISPLATIN;
D O I：
10.1089/scd.2019.0131
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEV) are the primary effective source in stem cell-dependent regenerative medicine due to their preponderances over direct MSC implantation. An increasing number of studies have been carried out on MSC-sEV derived from different types of cells, and their function of accelerating tissue repair was proved. However, only a few researches were able to demonstrate the functional cargoes in MSC-sEV or their mechanisms in promoting tissue recovery. In this review, we present current achievements in discovering MSC-sEV-carried RNAs and proteins as promoters in tissue regeneration. Their therapeutic function includes modulating immune reactivity, promoting angiogenesis, and accelerating cell proliferation and migration through orchestrates of cell signaling pathways.
引用
收藏
页码：15 / 24
页数：10
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