Regeneration-Related Functional Cargoes in Mesenchymal Stem Cell-Derived Small Extracellular Vesicles

被引：8
作者：
Zhu, Zhongyi [1 ,2 ]
Zhang, Yijing [1 ,2 ,3 ]
Wu, Ligang [4 ,5 ]
Hua, Keqin [1 ,2 ]
Ding, Jingxin [1 ,2 ]
机构：
[1] Fudan Univ, Obstet & Gynecol Hosp, Dept Gynecol, Shanghai, Peoples R China
[2] Shanghai Key Lab Female Reprod Endocrine Related, Shanghai, Peoples R China
[3] Shanghai Ji Ai Genet & IVF Inst, Shanghai, Peoples R China
[4] Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, State Key Lab Mol Biol, Shanghai, Peoples R China
[5] Univ Chinese Acad Sci, Shanghai, Peoples R China
来源：
STEM CELLS AND DEVELOPMENT | 2020年 / 29卷 / 01期
关键词：
stem cell; regeneration; small extracellular vesicle; microRNA; lncRNA; protein; STROMAL CELLS; IN-VITRO; EXOSOMES; MICRORNAS; INJURY; DIFFERENTIATION; ENHANCE; REPAIR; MODULATION; CISPLATIN;
D O I：
10.1089/scd.2019.0131
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEV) are the primary effective source in stem cell-dependent regenerative medicine due to their preponderances over direct MSC implantation. An increasing number of studies have been carried out on MSC-sEV derived from different types of cells, and their function of accelerating tissue repair was proved. However, only a few researches were able to demonstrate the functional cargoes in MSC-sEV or their mechanisms in promoting tissue recovery. In this review, we present current achievements in discovering MSC-sEV-carried RNAs and proteins as promoters in tissue regeneration. Their therapeutic function includes modulating immune reactivity, promoting angiogenesis, and accelerating cell proliferation and migration through orchestrates of cell signaling pathways.
引用
收藏
页码：15 / 24
页数：10
相关论文
共 80 条
[61]   Mesenchymal Stromal/stem Cell-derived Extracellular Vesicles Promote Human Cartilage Regeneration In Vitro [J].
Vonk, Lucienne A. ;
van Dooremalen, Sanne F. J. ;
Liv, Nalan ;
Klumperman, Judith ;
Coffer, Paul J. ;
Saris, Daniel B. F. ;
Lorenowicz, Magdalena J. .
THERANOSTICS, 2018, 8 (04) :906-920
[62]   Engineering Bioactive Self-Healing Antibacterial Exosomes Hydrogel for Promoting Chronic Diabetic Wound Healing and Complete Skin Regeneration [J].
Wang, Chenggui ;
Wang, Min ;
Xu, Tianzhen ;
Zhang, Xingxing ;
Lin, Cai ;
Gao, Weiyang ;
Xu, Huazi ;
Lei, Bo ;
Mao, Cong .
THERANOSTICS, 2019, 9 (01) :65-76
[63]   HucMSC exosome-transported 14-3-3ζ prevents the injury of cisplatin to HK-2 cells by inducing autophagy in vitro [J].
Wang, Juanjuan ;
Jia, Haoyuan ;
Zhang, Bin ;
Yin, Lei ;
Mao, Fei ;
Yu, Jing ;
Ji, Cheng ;
Xu, Xiao ;
Yan, Yongmin ;
Xu, Wenrong ;
Qian, Hui .
CYTOTHERAPY, 2018, 20 (01) :29-44
[64]   Synapsin I Is an Oligomannose-Carrying Glycoprotein, Acts As an Oligomannose-Binding Lectin, and Promotes Neurite Outgrowth and Neuronal Survival When Released via Glia-Derived Exosomes [J].
Wang, Shiwei ;
Cesca, Fabrizia ;
Loers, Gabriele ;
Schweizer, Michaela ;
Buck, Friedrich ;
Benfenati, Fabio ;
Schachner, Melitta ;
Kleene, Ralf .
JOURNAL OF NEUROSCIENCE, 2011, 31 (20) :7275-7290
[65]   Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth [J].
Xin, Hongqi ;
Li, Yi ;
Buller, Ben ;
Katakowski, Mark ;
Zhang, Yi ;
Wang, Xinli ;
Shang, Xia ;
Zhang, Zheng Gang ;
Chopp, Michael .
STEM CELLS, 2012, 30 (07) :1556-1564
[66]   hucMSC Exosome-Derived GPX1 Is Required for the Recovery of Hepatic Oxidant Injury [J].
Yan, Yongmin ;
Jiang, Wenqian ;
Tan, Youwen ;
Zou, Shengqiang ;
Zhang, Hongguang ;
Mao, Fei ;
Gong, Aihua ;
Qian, Hui ;
Xu, Wenrong .
MOLECULAR THERAPY, 2017, 25 (02) :465-479
[67]   Cellular functions of long noncoding RNAs [J].
Yao, Run-Wen ;
Wang, Yang ;
Chen, Ling-Ling .
NATURE CELL BIOLOGY, 2019, 21 (05) :542-551
[68]   Extracellular vesicles from human-induced pluripotent stem cell-derived mesenchymal stromal cells (hiPSC-MSCs) protect against renal ischemia/reperfusion injury via delivering specificity protein (SP1) and transcriptional activating of sphingosine kinase 1 and inhibiting necroptosis [J].
Yuan, Xiaodong ;
Li, Dawei ;
Chen, Xiaosong ;
Han, Conghui ;
Xu, Longmei ;
Huang, Tao ;
Dong, Zhen ;
Zhang, Ming .
CELL DEATH & DISEASE, 2017, 8
[69]   HucMSC Exosome-Delivered 14-3-3 Orchestrates Self-Control of the Wnt Response via Modulation of YAP During Cutaneous Regeneration [J].
Zhang, Bin ;
Shi, Yinghong ;
Gong, Aihua ;
Pan, Zhaoji ;
Shi, Hui ;
Yang, Huan ;
Fu, Hailong ;
Yan, Yongmin ;
Zhang, Xu ;
Wang, Mei ;
Zhu, Wei ;
Qian, Hui ;
Xu, Wenrong .
STEM CELLS, 2016, 34 (10) :2485-2500
[70]   HucMSC-Exosome Mediated-Wnt4 Signaling Is Required for Cutaneous Wound Healing [J].
Zhang, Bin ;
Wang, Mei ;
Gong, Aihua ;
Zhang, Xu ;
Wu, Xiaodan ;
Zhu, Yanhua ;
Shi, Hui ;
Wu, Lijun ;
Zhu, Wei ;
Qian, Hui ;
Xu, Wenrong .
STEM CELLS, 2015, 33 (07) :2158-2168
12345678