Regeneration-Related Functional Cargoes in Mesenchymal Stem Cell-Derived Small Extracellular Vesicles

被引：8
作者：
Zhu, Zhongyi [1 ,2 ]
Zhang, Yijing [1 ,2 ,3 ]
Wu, Ligang [4 ,5 ]
Hua, Keqin [1 ,2 ]
Ding, Jingxin [1 ,2 ]
机构：
[1] Fudan Univ, Obstet & Gynecol Hosp, Dept Gynecol, Shanghai, Peoples R China
[2] Shanghai Key Lab Female Reprod Endocrine Related, Shanghai, Peoples R China
[3] Shanghai Ji Ai Genet & IVF Inst, Shanghai, Peoples R China
[4] Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, State Key Lab Mol Biol, Shanghai, Peoples R China
[5] Univ Chinese Acad Sci, Shanghai, Peoples R China
来源：
STEM CELLS AND DEVELOPMENT | 2020年 / 29卷 / 01期
关键词：
stem cell; regeneration; small extracellular vesicle; microRNA; lncRNA; protein; STROMAL CELLS; IN-VITRO; EXOSOMES; MICRORNAS; INJURY; DIFFERENTIATION; ENHANCE; REPAIR; MODULATION; CISPLATIN;
D O I：
10.1089/scd.2019.0131
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEV) are the primary effective source in stem cell-dependent regenerative medicine due to their preponderances over direct MSC implantation. An increasing number of studies have been carried out on MSC-sEV derived from different types of cells, and their function of accelerating tissue repair was proved. However, only a few researches were able to demonstrate the functional cargoes in MSC-sEV or their mechanisms in promoting tissue recovery. In this review, we present current achievements in discovering MSC-sEV-carried RNAs and proteins as promoters in tissue regeneration. Their therapeutic function includes modulating immune reactivity, promoting angiogenesis, and accelerating cell proliferation and migration through orchestrates of cell signaling pathways.
引用
收藏
页码：15 / 24
页数：10
相关论文
共 80 条
[1]   Vascular endothelial growth factor mediates the therapeutic efficacy of mesenchymal stem cell-derived extracellular vesicles against neonatal hyperoxic lung injury [J].
Ahn, So Yoon ;
Park, Won Soon ;
Kim, Young Eun ;
Sung, Dong Kyung ;
Sung, Se In ;
Ahn, Jee Yin ;
Chang, Yun Sil .
EXPERIMENTAL AND MOLECULAR MEDICINE, 2018, 50 :1-12
[2]   The functions of animal microRNAs [J].
Ambros, V .
NATURE, 2004, 431 (7006) :350-355
[3]   Exosomes from acellular Wharton's jelly of the human umbilical cord promotes skin wound healing [J].
Bakhtyar, Nazihah ;
Jeschke, Marc G. ;
Herer, Elaine ;
Sheikholeslam, Mohammadali ;
Amini-Nik, Saeid .
STEM CELL RESEARCH & THERAPY, 2018, 9
[4]   Effect of Exosomes from Rat Adipose-Derived Mesenchymal Stem Cells on Neurite Outgrowth and Sciatic Nerve Regeneration After Crush Injury [J].
Bucan, Vesna ;
Vaslaitis, Desiree ;
Peck, Claas-Tido ;
Strauss, Sarah ;
Vogt, Peter M. ;
Radtke, Christine .
MOLECULAR NEUROBIOLOGY, 2019, 56 (03) :1812-1824
[5]   Extracellular Vesicle-Educated Macrophages Promote Early Achilles Tendon Healing [J].
Chamberlain, Connie S. ;
Clements, Anna E. B. ;
Kink, John A. ;
Choi, Ugeun ;
Baer, Geoffrey S. ;
Halanski, Matthew A. ;
Hematti, Peiman ;
Vanderby, Ray .
STEM CELLS, 2019, 37 (05) :652-662
[6]   Mesenchymal stem cell exosomes enhance periodontal ligament cell functions and promote periodontal regeneration [J].
Chew, Jacob Ren Jie ;
Chuah, Shang Jiunn ;
Teo, Kristeen Ye Wen ;
Zhang, Shipin ;
Lai, Ruenn Chai ;
Fu, Jia Hui ;
Lim, Lum Peng ;
Lim, Sai Kiang ;
Toh, Wei Seong .
ACTA BIOMATERIALIA, 2019, 89 :252-264
[7]   Mesenchymal stem/stromal cell extracellular vesicles: From active principle to next generation drug delivery system [J].
Crivelli, Barbara ;
Chlapanidas, Theodora ;
Perteghella, Sara ;
Lucarelli, Enrico ;
Pascucci, Luisa ;
Brini, Anna Teresa ;
Ferrero, Ivana ;
Marazzi, Mario ;
Pessina, Augusto ;
Torre, Maria Luisa .
JOURNAL OF CONTROLLED RELEASE, 2017, 262 :104-117
[8]   A Regulatory miRNA-mRNA Network Is Associated with Tissue Repair Induced by Mesenchymal Stromal Cells in Acute Kidney Injury [J].
de Almeida, Danilo Candido ;
Bassi, Enio Jose ;
Azevedo, Hatylas ;
Anderson, Leticia ;
Taemi Origassa, Clarice Silvia ;
Cenedeze, Marcos Antonio ;
de Andrade-Oliveira, Vinicius ;
Ferreira Felizardo, Raphael Jose ;
da Silva, Reinaldo Correia ;
Hiyane, Meire Ioshie ;
Semedo, Patricia ;
dos Reis, Marlene Antonia ;
Moreira-Filho, Carlos Alberto ;
Verjovski-Almeida, Sergio ;
Pacheco-Silva, Alvaro ;
Saraiva Camara, Niels Olsen .
FRONTIERS IN IMMUNOLOGY, 2017, 7
[9]   Vaginoplasty Using Acellular Porcine Small Intestinal Submucosa Graft in Two Patients with Meyer-von-Rokitansky-Kuster-Hauser Syndrome: A Prospective New Technique for Vaginal Reconstruction [J].
Ding, Jing-Xin ;
Zhang, Xu-yin ;
Chen, Li-mei ;
Hua, Ke-Qin .
GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 2013, 75 (02) :93-96
[10]   MicroRNA and mRNA cargo of extracellular vesicles from porcine adipose tissue-derived mesenchymal stem cells [J].
Eirin, Alfonso ;
Riester, Scott M. ;
Zhu, Xiang-Yang ;
Tang, Hui ;
Evans, Jared M. ;
O'Brien, Daniel ;
van Wijnen, Andre J. ;
Lerman, Lilach O. .
GENE, 2014, 551 (01) :55-64
12345678