Anti-MDA5 Antibody-positive Dermatomyositis with Rapidly Progressive Interstitial Pneumonia Presenting with Nephrotic Syndrome during Treatment with Corticosteroids and Cyclosporine

被引：3

作者：

Kawamoto, Shinya ^{[1
]}

Abe, Toshihiro ^{[1
]}

Nagahori, Katsuhiro ^{[1
]}

Yoshino, Atsunori ^{[1
]}

Fujii, Akiko ^{[2
]}

Ono, Yuko ^{[2
]}

Ueda, Yoshihiko ^{[2
]}

Takeda, Tetsuro ^{[1
]}

机构：

[1] Dokkyo Med Univ, Saitama Med Ctr, Dept Nephrol, Koshigaya, Japan

[2] Dokkyo Med Univ, Saitama Med Ctr, Dept Pathol, Koshigaya, Japan

来源：

INTERNAL MEDICINE | 2022年 / 61卷 / 13期

关键词：

Key words; anti-MDA5 antibody-positive dermatomyositis; rapidly progressive interstitial pneumonia; nephrotic syndrome; thrombotic microangiopathy; cyclosporine; THROMBOTIC MICROANGIOPATHY; RENAL INVOLVEMENT; PLASMA-EXCHANGE; REGISTRY;

D O I：

10.2169/internalmedicine.8311-21

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 50-year-old Japanese woman with anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5 antibody)-positive dermatomyositis presenting with rapidly progressive interstitial pneumonia was treated with corticosteroids and cyclosporine. She developed nephrotic syndrome during the treatment regimen with corticosteroids and cyclosporine. A kidney biopsy revealed a thrombotic microangiopathy (TMA) glomerular lesion. Anti-MDA5 antibody-positive dermatomyositis is prone to severe interstitial lung disease (ILD) and is often exacerbated and refractory to treatment. Renal symptoms might be due to TMA of the kidney, and this may be a sign that more intensive treatment is needed. Patients sometimes develop acute kidney injury, which may be due to the TMA.

引用

页码：2007 / 2012

页数：6

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