Effect of anti-ganglioside antibody in experimental Trypanosoma brucei infection in mice

被引：0
|
作者：
Tsujimura, Y
Watarai, S
Uemura, A
Ohnishi, Y
Kodama, H
机构：
[1] Osaka Prefecture Univ, Grad Sch Agr & Biol Sci, Div Vet Sci, Lab Vet Immunol, Sakai, Osaka 5998531, Japan
[2] Osaka Prefecture Univ, Grad Sch Agr & Biol Sci, Div Vet Sci, Lab Int Epidem, Sakai, Osaka 591, Japan
来源：
RESEARCH IN VETERINARY SCIENCE | 2005年 / 78卷 / 03期
关键词：
anti-ganglioside antibody; ganglioside; protozoan disease; Trypanosoma brucei;
D O I：
10.1016/j.rvsc.2004.09.003
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The effect of antibody against ganglioside antigen on Trypanosoma brucei parasites was examined in vitro and ill Vivo Using antiGanalioside GM1 (AGIM-1) monoclonal antibody. The antibody showed complement-dependent cytotoxicity against T brucei with mouse complement. Furthermore. mice given AGM-1 were challenged intraperitoneally with T brucei. Although all non-treated control mice died within six days after infection, all of AGM-1-injected mice had survived by six days post-infection. These data suggest that antibody against ganglioside antigen on T brucei has potential in protection against T brucei infection. (c) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：245 / 247
页数：3
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