Bone morphogenetic proteins, activins, and growth and differentiation factors in tumor immunology and immunotherapy resistance

被引：3
作者：
Ganjoo, Shonik [1 ]
Puebla-Osorio, Nahum [1 ]
Nanez, Selene [1 ]
Hsu, Ethan [1 ]
Voss, Tiffany [1 ]
Barsoumian, Hampartsoum [1 ]
Duong, Lisa K. [1 ]
Welsh, James W. [1 ]
Cortez, Maria Angelica [1 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA
来源：
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
关键词：
TGF-bsuperfamily; bone morphogenetic proteins; activins; growth and differentiation factors; immunotherapy; cancer; FACTOR-BETA SUPERFAMILY; LYMPH-NODE METASTASIS; TGF-BETA; BREAST-CANCER; SIGNALING PATHWAYS; THERAPEUTIC TARGET; CELL-PROLIFERATION; T-CELLS; GROWTH/DIFFERENTIATION FACTOR-5; GERMLINE MUTATIONS;
D O I：
10.3389/fimmu.2022.1033642
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The TGF-beta superfamily is a group of secreted polypeptides with key roles in exerting and regulating a variety of physiologic effects, especially those related to cell signaling, growth, development, and differentiation. Although its central member, TGF-beta, has been extensively reviewed, other members of the family-namely bone morphogenetic proteins (BMPs), activins, and growth and differentiation factors (GDFs)-have not been as thoroughly investigated. Moreover, although the specific roles of TGF-beta signaling in cancer immunology and immunotherapy resistance have been extensively reported, little is known of the roles of BMPs, activins, and GDFs in these domains. This review focuses on how these superfamily members influence key immune cells in cancer progression and resistance to treatment.
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页数：14
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共 174 条
  • [61] Activin A inhibits vascular endothelial cell growth and suppresses tumour angiogenesis in gastric cancer
    Kaneda, H.
    Arao, T.
    Matsumoto, K.
    De Velasco, M. A.
    Tamura, D.
    Aomatsu, K.
    Kudo, K.
    Sakai, K.
    Nagai, T.
    Fujita, Y.
    Tanaka, K.
    Yanagihara, K.
    Yamada, Y.
    Okamoto, I.
    Nakagawa, K.
    Nishio, K.
    [J]. BRITISH JOURNAL OF CANCER, 2011, 105 (08) : 1210 - 1217
  • [62] Bone Morphogenetic Proteins
    Katagiri, Takenobu
    Watabe, Tetsuro
    [J]. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2016, 8 (06):
  • [63] Clinical significance of BMP7 in human colorectal cancer
    Kazuo, Motoyama
    Fumiaki, Tanaka
    Yoshimasa, Kosaka
    Koshi, Mimori
    Hiroyuki, Uetake
    Hiroshi, Inoue
    Kenichi, Sugihara
    Mori, Masaki
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2008, 15 (05) : 1530 - 1537
  • [64] Activin A immunoexpression as predictor of occult lymph node metastasis and overall survival in oral tongue squamous cell carcinoma
    Kelner, Natalie
    Rodrigues, Priscila Campioni
    Bufalino, Andreia
    Fonseca, Felipe Paiva
    dos Santos-Silva, Alan Roger
    Costa Miguel, Marcia Cristina
    Lopes Pinto, Clovis Antonio
    Paes Leme, Adriana Franco
    Graner, Edgard
    Salo, Tuula
    Kowalski, Luiz Paulo
    Coletta, Ricardo D.
    [J]. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2015, 37 (04): : 479 - 486
  • [65] A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis
    Kerr, Georgina
    Sheldon, Helen
    Chaikuad, Apirat
    Alfano, Ivan
    von Delft, Frank
    Bullock, Alex N.
    Harris, Adrian L.
    [J]. ANGIOGENESIS, 2015, 18 (02) : 209 - 217
  • [66] Novel therapies emerging in oncology to target the TGF-β pathway
    Kim, Byung-Gyu
    Malek, Ehsan
    Choi, Sung Hee
    Ignatz-Hoover, James J.
    Driscoll, James J.
    [J]. JOURNAL OF HEMATOLOGY & ONCOLOGY, 2021, 14 (01)
  • [67] Kim IY, 1998, CLIN CANCER RES, V4, P1625
  • [68] Kim IY, 1996, CANCER RES, V56, P44
  • [69] Macrophage inhibitory cytokine-1 activates AKT and ERK-1/2 via the transactivation of ErbB2 in human breast and gastric cancer cells
    Kim, Kwang-Kyu
    Lee, Jung Joon
    Yang, Young
    You, Kwan-Hee
    Lee, Jeong-Hyung
    [J]. CARCINOGENESIS, 2008, 29 (04) : 704 - 712
  • [70] CRP Stimulates GDF15 Expression in Endothelial Cells through p53
    Kim, Yoonseo
    Noren Hooten, Nicole
    Evans, Michele K.
    [J]. MEDIATORS OF INFLAMMATION, 2018, 2018
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