Bone morphogenetic proteins, activins, and growth and differentiation factors in tumor immunology and immunotherapy resistance

被引：3
作者：
Ganjoo, Shonik [1 ]
Puebla-Osorio, Nahum [1 ]
Nanez, Selene [1 ]
Hsu, Ethan [1 ]
Voss, Tiffany [1 ]
Barsoumian, Hampartsoum [1 ]
Duong, Lisa K. [1 ]
Welsh, James W. [1 ]
Cortez, Maria Angelica [1 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA
来源：
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
关键词：
TGF-bsuperfamily; bone morphogenetic proteins; activins; growth and differentiation factors; immunotherapy; cancer; FACTOR-BETA SUPERFAMILY; LYMPH-NODE METASTASIS; TGF-BETA; BREAST-CANCER; SIGNALING PATHWAYS; THERAPEUTIC TARGET; CELL-PROLIFERATION; T-CELLS; GROWTH/DIFFERENTIATION FACTOR-5; GERMLINE MUTATIONS;
D O I：
10.3389/fimmu.2022.1033642
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The TGF-beta superfamily is a group of secreted polypeptides with key roles in exerting and regulating a variety of physiologic effects, especially those related to cell signaling, growth, development, and differentiation. Although its central member, TGF-beta, has been extensively reviewed, other members of the family-namely bone morphogenetic proteins (BMPs), activins, and growth and differentiation factors (GDFs)-have not been as thoroughly investigated. Moreover, although the specific roles of TGF-beta signaling in cancer immunology and immunotherapy resistance have been extensively reported, little is known of the roles of BMPs, activins, and GDFs in these domains. This review focuses on how these superfamily members influence key immune cells in cancer progression and resistance to treatment.
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页数：14
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