Bone morphogenetic proteins, activins, and growth and differentiation factors in tumor immunology and immunotherapy resistance

被引：5

作者：

Ganjoo, Shonik ^{[1
]}

Puebla-Osorio, Nahum ^{[1
]}

Nanez, Selene ^{[1
]}

Hsu, Ethan ^{[1
]}

Voss, Tiffany ^{[1
]}

Barsoumian, Hampartsoum ^{[1
]}

Duong, Lisa K. ^{[1
]}

Welsh, James W. ^{[1
]}

Cortez, Maria Angelica ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

关键词：

TGF-bsuperfamily; bone morphogenetic proteins; activins; growth and differentiation factors; immunotherapy; cancer; FACTOR-BETA SUPERFAMILY; LYMPH-NODE METASTASIS; TGF-BETA; BREAST-CANCER; SIGNALING PATHWAYS; THERAPEUTIC TARGET; CELL-PROLIFERATION; T-CELLS; GROWTH/DIFFERENTIATION FACTOR-5; GERMLINE MUTATIONS;

D O I：

10.3389/fimmu.2022.1033642

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The TGF-beta superfamily is a group of secreted polypeptides with key roles in exerting and regulating a variety of physiologic effects, especially those related to cell signaling, growth, development, and differentiation. Although its central member, TGF-beta, has been extensively reviewed, other members of the family-namely bone morphogenetic proteins (BMPs), activins, and growth and differentiation factors (GDFs)-have not been as thoroughly investigated. Moreover, although the specific roles of TGF-beta signaling in cancer immunology and immunotherapy resistance have been extensively reported, little is known of the roles of BMPs, activins, and GDFs in these domains. This review focuses on how these superfamily members influence key immune cells in cancer progression and resistance to treatment.

引用

页数：14

共 174 条

[11] BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-β receptor type I ALK5 [J].

Bollum, Lise K. ;

Huse, Kanutte ;

Oksvold, Morten P. ;

Bai, Baoyan ;

Hilden, Vera I. ;

Forfang, Lise ;

Yoon, Sun Ok ;

Walchli, Sebastien ;

Smeland, Erlend B. ;

Myklebust, June H. .

PLOS ONE, 2017, 12 (05)

[12] Cold Tumors: A Therapeutic Challenge for Immunotherapy [J].

Bonaventura, Paola ;

Shekarian, Tala ;

Alcazer, Vincent ;

Valladeau-Guilemond, Jenny ;

Valsesia-Wittmann, Sandrine ;

Amigorena, Sebastian ;

Caux, Christophe ;

Depil, Stephane .

FRONTIERS IN IMMUNOLOGY, 2019, 10

[13] Bone Morphogenetic Proteins: A critical review [J].

Bragdon, Beth ;

Moseychuk, Oleksandra ;

Saldanha, Sven ;

King, Daniel ;

Julian, Joanne ;

Nohe, Anja .

CELLULAR SIGNALLING, 2011, 23 (04) :609-620

[14]

Breit S, 2000, CANCER RES, V60, P4596

[15] Crystal structure of BMP-9 and functional interactions with pro-region and receptors [J].

Brown, MA ;

Zhao, QH ;

Baker, KA ;

Naik, C ;

Chen, C ;

Pukac, L ;

Singh, M ;

Tsareva, T ;

Parice, Y ;

Mahoney, A ;

Roschke, V ;

Sanyal, I ;

Choe, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (26) :25111-25118

[16] Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-β kinase antagonist, in mice [J].

Bueno, Lorea ;

de Alwis, Dinesh P. ;

Pitou, Celine ;

Yingling, Jonathan ;

Lahn, Michael ;

Glatt, Sophie ;

Troconiz, Inaki F. .

EUROPEAN JOURNAL OF CANCER, 2008, 44 (01) :142-150

[17] BMP4 Inhibits Breast Cancer Metastasis by Blocking Myeloid-Derived Suppressor Cell Activity [J].

Cao, Yuan ;

Slaney, Clare Y. ;

Bidwell, Bradley N. ;

Parker, Belinda S. ;

Johnstone, Cameron N. ;

Rautela, Jai ;

Eckhardt, Bedrich L. ;

Anderson, Robin L. .

CANCER RESEARCH, 2014, 74 (18) :5091-5102

[18] Bone morphogenetic protein 2 (BMP-2) enhances BMP-3, BMP-4, and bone cell differentiation marker gene expression during the induction of mineralized bone matrix formation in cultures of fetal rat calvarial osteoblasts [J].

Chen, D ;

Harris, MA ;

Rossini, G ;

Dunstan, CR ;

Dallas, SL ;

Feng, JQ ;

Mundy, GR ;

Harris, SE .

CALCIFIED TISSUE INTERNATIONAL, 1997, 60 (03) :283-290

[19] Prostate-derived factor as a paracrine and autocrine factor for the proliferation of androgen receptor-positive human prostate cancer cells [J].

Chen, Siu-Ju ;

Karan, Dev ;

Johansson, Sonny L. ;

Lin, Fen-Fen ;

Zeckser, Jeffrey ;

Singh, Ajay P. ;

Batra, Surinder K. ;

Lin, Ming-Fong .

PROSTATE, 2007, 67 (05) :557-571

[20] Immunoregulation by members of the TGFβ superfamily [J].

Chen, WanJun ;

ten Dijke, Peter .

NATURE REVIEWS IMMUNOLOGY, 2016, 16 (12) :723-740

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