Friedel-Crafts Arylation of a-Hydroxy Ketones: Synthesis of 1,2,2,2-Tetraarylethanones

被引：17
作者：
Kumar, Anil [1 ,2 ]
Singh, Tej V. [1 ,2 ]
Thomas, Sajesh P. [3 ]
Venugopalan, Paloth [1 ,2 ]
机构：
[1] Punjab Univ, Dept Chem, Chandigarh 160014, India
[2] Punjab Univ, Ctr Adv Studies Chem, Chandigarh 160014, India
[3] Indian Inst Sci, Solid State & Struct Chem Unit, Bangalore 560012, Karnataka, India
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 2015卷 / 06期
关键词：
Synthetic methods; Arylation; Ketones; Carbocations; CATALYZED ALPHA-ARYLATION; INDUCE APOPTOSIS; CATIONS; MOLECULES; TAMOXIFEN;
D O I：
10.1002/ejoc.201403438
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Friedel-Crafts arylation of a-hydroxy ketones such as 2-hydroxy- 1,2,2-triarylethanones has been achieved with a variety of arenes and heteroarenes in the presence of Lewis or Bronsted acids. Both sterically hindered and unhindered 1,2,2,2-tetrarylethanones are formed in good to excellent yields by using a stoichiometric amount of triflic acid. The intermediacy of an a-keto carbenium ion has been proposed.
引用
收藏
页码：1226 / 1234
页数：9
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