Electroporation-Based Technologies for Medicine: Principles, Applications, and Challenges

被引：641

作者：

Yarmush, Martin L. ^{[1
,2
,3
]}

Golberg, Alexander ^{[1
,2
]}

Sersa, Gregor ^{[4
]}

Kotnik, Tadej ^{[5
]}

Miklavcic, Damijan ^{[5
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Engn Med,Dept Surg, Boston, MA 02114 USA

[2] Shriners Burn Hosp Children, Boston, MA 02114 USA

[3] Rutgers State Univ, Dept Biomed Engn, Piscataway, NJ 08854 USA

[4] Inst Oncol Ljubljana, Dept Expt Oncol, SI-1000 Ljubljana, Slovenia

[5] Univ Ljubljana, Fac Elect Engn, Dept Biomed Engn, SI-1000 Ljubljana, Slovenia

来源：

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 16 | 2014年 / 16卷

关键词：

pulsed electric field; electropermeabilization; electrochemotherapy; gene electrotransfer; DNA vaccination; irreversible electroporation; ELECTRICAL-IMPEDANCE TOMOGRAPHY; STANDARD OPERATING PROCEDURES; TRANSDERMAL DRUG-DELIVERY; CYTOTOXIC T-LYMPHOCYTES; 1ST CLINICAL-TRIAL; SINGLE-CELL LEVEL; LOW-VOLTAGE PULSE; IRREVERSIBLE ELECTROPORATION; IN-VIVO; GENE ELECTROTRANSFER;

D O I：

10.1146/annurev-bioeng-071813-104622

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

When high-amplitude, short-duration pulsed electric fields are applied to cells and tissues, the permeability of the cell membranes and tissue is increased. This increase in permeability is currently explained by the temporary appearance of aqueous pores within the cell membrane, a phenomenon termed electroporation. During the past four decades, advances in fundamental and experimental electroporation research have allowed for the translation of electroporation-based technologies to the clinic. In this review, we describe the theory and current applications of electroporation in medicine and then discuss current challenges in electroporation research and barriers to a more extensive spread of these clinical applications.

引用

页码：295 / 320

页数：26

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