Characterization of a Hierarchical Network of Hyaluronic Acid/Gelatin Composite for use as a Smart Injectable Biomaterial

被引：40

作者：

Heris, Hossein K. ^{[1
]}

Rahmat, Meysam ^{[1
]}

Mongeau, Luc ^{[1
]}

机构：

[1] McGill Univ, Dept Mech Engn, Montreal, PQ H3A 2K6, Canada

来源：

MACROMOLECULAR BIOSCIENCE | 2012年 / 12卷 / 02期

关键词：

cell adhesion; hierarchical networks; hybrid microgels; smart drug delivery; tissue engineering; FIBROBLAST-GROWTH-FACTOR; VOCAL FOLD; EXTRACELLULAR-MATRIX; GELATIN MICROSPHERES; HYBRID MICROGELS; CELL-MIGRATION; TISSUE-REPAIR; HYDROGELS; ACID; DELIVERY;

D O I：

10.1002/mabi.201100335

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hybrid HA/Ge hydrogel particles are embedded in a secondary HA network to improve their structural integrity. The internal microstructure of the particles is imaged through TEM. CSLM is used to identify the location of the Ge molecules in the microgels. Through indentation tests, the Young's modulus of the individual particles is found to be 22 +/- 2.5 kPa. The overall shear modulus of the composite is 75 +/- 15 Pa at 1 Hz. The mechanical properties of the substrate are found to be viable for cell adhesion. The particles' diameter at pH=8 is twice that at pH=5. The pH sensitivity is found to be appropriate for smart drug delivery. Based on their mechanical and structural properties, HAGe hierarchical materials may be well suited for use as injectable biomaterials for tissue reconstruction.

引用

页码：202 / 210

页数：9

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