Serum and urine selenium concentrations as indicators of body status in patients with diabetes mellitus

Serum and urine selenium levels were determined in patients with diabetes by hydride generation atomic absorption spectrometry. Mean serum selenium concentrations measured in patients with diabetes mellitus (64.9 +/- 22.8 mu g/l) were significantly lower than those determined in the control group (74.9 +/- 27.3 mu g/l) (P < 0.05). Mean serum selenium concentrations were not significantly different between the two groups of diabetic patients considered (P > 0.05). Mean urine selenium concentration in diabetic patients (18.8 +/- 10.7 mu g/l) were not significantly different from those measured in the control group (20.2 +/- 10.1 mu g/l) (P > 0.05). No significant differences in serum and urine selenium levels were found if related to sex of patients (P > 0.05). Application of linear regression analysis to serum and urine selenium levels and patients' age showed a non-statistically significant correlation (P > 0.05). Given the marked overlap between the two ranges of the populations, the predictive values of serum selenium in diabetic patients are low. (C) 1999 Elsevier Science B.V. All rights reserved.