Sinapic acid safeguards cardiac mitochondria from damage in isoproterenol-induced myocardial infarcted rats

被引:16
作者
Stanely Mainzen Prince, P. [1 ]
Dey, Pinaki [2 ]
Roy, S. J. [1 ]
机构
[1] Annamalai Univ, Dept Biochem & Biotechnol, Annamalainagar 608002, Tamil Nadu, India
[2] Karunya Inst Technol & Sci, Dept Biotechnol, Coimbatore, Tamil Nadu, India
关键词
antioxidants; mitochondrial damage; myocardial infarction; myoglobin; sinapic acid; ASSAY;
D O I
10.1002/jbt.22556
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Myocardial infarction (MI) is a life-threatening disease. In this study, we examined the anti-mitochondrial damaging effects of sinapic acid (SA) in isoproterenol (ISO)-induced myocardial infarcted rats. Myocardial infarcted rats were prepared by injecting ISO (100 mg/kg body weight) on the 9th and 10th day. Rats were pretreated and cotreated with SA (12 mg/kg body weight) orally, daily for 10 days. A considerable increase in serum lactate dehydrogenase, creatine kinase, myoglobin, and cardiac troponin-T was noticed in the ISO-induced rats. ISO also significantly amplified lipid peroxidation and calcium ions, and depleted the antioxidant system and mitochondrial enzymes in rat's heart mitochondria. SA treatment improved the distorted above- mentioned biochemical parameters in ISO-treated rats with its anti-mitochondrial damaging effects. This ultrastructural study on heart mitochondria and in vitro studies also confirmed the effects of SA. The current findings are suggestive of SA's cardioprotective effects.
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页数:6
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