Crystal structures of the Mycobacterium tuberculosis secretory antigen alanine dehydrogenase (Rv2780) in apo and ternary complex forms captures "open" and "closed" enzyme conformations

被引:27
作者
Tripathi, Sarvind Mani [1 ]
Ramachandran, Ravishankar [1 ]
机构
[1] Cent Drug Res Inst, Mol & Struct Biol Div, Lucknow 226001, Uttar Pradesh, India
关键词
M. tuberculosis L-alanine dehydrogenase; NAD; pyruvate; crystal structure; ternary complex; dehydrogenases; enzyme mechanism;
D O I
10.1002/prot.22101
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:1089 / 1095
页数:7
相关论文
共 37 条
[1]  
*ACC, 2000, ACCELRYS VER 1 1, P92121
[2]   THE CCP4 SUITE - PROGRAMS FOR PROTEIN CRYSTALLOGRAPHY [J].
BAILEY, S .
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 1994, 50 :760-763
[3]   A ROLE FOR QUATERNARY STRUCTURE IN THE SUBSTRATE-SPECIFICITY OF LEUCINE DEHYDROGENASE [J].
BAKER, PJ ;
TURNBULL, AP ;
SEDELNIKOVA, SE ;
STILLMAN, TJ ;
RICE, DW .
STRUCTURE, 1995, 3 (07) :693-705
[4]   Analysis of the structure and substrate binding of Phormidium lapideum alanine dehydrogenase [J].
Baker, PJ ;
Sawa, Y ;
Shibata, H ;
Sedelnikova, SE ;
Rice, DW .
NATURE STRUCTURAL BIOLOGY, 1998, 5 (07) :561-567
[5]   Determinants of substrate specificity in the superfamily of amino acid dehydrogenases [J].
Baker, PJ ;
Waugh, ML ;
Wang, XG ;
Stillman, TJ ;
Turnbull, AP ;
Engel, PC ;
Rice, DW .
BIOCHEMISTRY, 1997, 36 (51) :16109-16115
[6]   Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling [J].
Betts, JC ;
Lukey, PT ;
Robb, LC ;
McAdam, RA ;
Duncan, K .
MOLECULAR MICROBIOLOGY, 2002, 43 (03) :717-731
[7]  
BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[8]   Complex pattern of Mycobacterium marinum gene expression during long-term granulomatous infection [J].
Chan, K ;
Knaak, T ;
Satkamp, L ;
Humbert, O ;
Falkow, S ;
Ramakrishnan, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (06) :3920-3925
[9]   ALIGN: a program to superimpose protein coordinates, accounting for insertions and deletions [J].
Cohen, GH .
JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1997, 30 :1160-1161
[10]  
DeLano W. L., 2002, PYMOL