Aging of hematopoietic stem cells

被引：293
作者：
de Haan, Gerald [1 ]
Lazare, Seka Simone [1 ]
机构：
[1] Univ Groningen, Univ Med Ctr Groningen, European Res Inst Biol Ageing, A Deusinglaan 1, NL-9713 AV Groningen, Netherlands
来源：
BLOOD | 2018年 / 131卷 / 05期
关键词：
CLONAL HEMATOPOIESIS; SELF-RENEWAL; BONE-MARROW; IN-VIVO; LIFE-SPAN; MYELODYSPLASTIC SYNDROMES; DIFFERENTIATION PROGRAMS; PROLIFERATIVE CAPACITY; DEFICIENT MICE; BLOOD-CELLS;
D O I：
10.1182/blood-2017-06-746412
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hematopoietic stem cells (HSCs) ensure a balanced production of all blood cells throughout life. As they age, HSCs gradually lose their self-renewal and regenerative potential, whereas the occurrence of cellular derailment strongly increases. Here we review our current understanding of the molecular mechanisms that contribute to HSC aging. We argue that most of the causes that underlie HSC aging result from cell-intrinsic pathways, and reflect on which aspects of the aging process may be reversible. Because many hematological pathologies are strongly age-associated, strategies to intervene in aspects of the stem cell aging process may have significant clinical relevance.
引用
收藏
页码：479 / 487
页数：9
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