A New Hope in the Treatment of Intraventricular Haemorrhage in Preterm Infants: Mesenchymal Stem Cells

被引：12

作者：

Bozkaya, Davut ^{[1
]}

Ceran, Burak ^{[1
]}

Ozmen, Esra ^{[1
]}

Okman, Esin ^{[1
]}

Dizdar, Evrim Alyamac ^{[1
]}

Suna, Serife Oguz ^{[1
]}

Bozkaya, Ikbal Ok ^{[2
]}

机构：

[1] Ankara City Hosp Child Hlth & Dis, Div Neonatol, Ankara, Turkey

[2] Ankara City Hosp Child Hlth & Dis, Div Pediat Hematol, Ankara, Turkey

来源：

TURKISH NEUROSURGERY | 2022年 / 32卷 / 02期

关键词：

Intraventricular haemorrhage; Mesenchymal stem cells; Premature infant; Treatment; OUTCOMES;

D O I：

10.5137/1019-5149.JTN.34850-21.2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To date, there has been no effective treatment to prevent brain damage in premature infants or to prevent the development of post-hemorrhagic hydrocephalus (PHH) after severe intraventricular hemorrhage (IVH). Therefore, new, safe and effective treatment methods need to be developed to improve the prognosis of IVH, for which morbidity and mortality rates are high. Recent studies have shown that the strong immunomodulatory properties of mesenchymal stem cells (MSCs) have an anti-inflammatory effect after IVH, inhibiting the development of PHH and decreasing apoptosis and gliosis, thus improving the self-renewal ability of neuronal tissues. For this reason, MSCs transplantation after IVH is a promising treatment method. In this article, we present a case of gradeIII IVH who recovered after MSCs transplantation.

引用

页码：344 / 346

页数：3

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