Calcium Orthophosphate (CaPO4)-Based Bioceramics: Preparation, Properties, and Applications

被引:35
作者
Dorozhkin, Sergey, V [1 ]
机构
[1] Kudrinskaja Sq 1-155, Moscow 123242, Russia
关键词
calcium orthophosphates; hydroxyapatite; tricalcium phosphate; bioceramics; biomaterials; grafts; biomedical applications; tissue engineering; BETA-TRICALCIUM PHOSPHATE; POROUS HYDROXYAPATITE SCAFFOLDS; SOLID FREEFORM FABRICATION; BONE-GRAFT SUBSTITUTES; OF-THE-ART; TISSUE ENGINEERING APPROACH; MESENCHYMAL STEM-CELLS; IN-VITRO BIOACTIVITY; MECHANICAL-PROPERTIES; TRANSPARENT HYDROXYAPATITE;
D O I
10.3390/coatings12101380
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Various types of materials have been traditionally used to restore damaged bones. In the late 1960s, a strong interest was raised in studying ceramics as potential bone grafts due to their biomechanical properties. A short time later, such synthetic biomaterials were called bioceramics. Bioceramics can be prepared from diverse inorganic substances, but this review is limited to calcium orthophosphate (CaPO4)-based formulations only, due to its chemical similarity to mammalian bones and teeth. During the past 50 years, there have been a number of important achievements in this field. Namely, after the initial development of bioceramics that was just tolerated in the physiological environment, an emphasis was shifted towards the formulations able to form direct chemical bonds with the adjacent bones. Afterwards, by the structural and compositional controls, it became possible to choose whether the CaPO4-based implants would remain biologically stable once incorporated into the skeletal structure or whether they would be resorbed over time. At the turn of the millennium, a new concept of regenerative bioceramics was developed, and such formulations became an integrated part of the tissue engineering approach. Now, CaPO4-based scaffolds are designed to induce bone formation and vascularization. These scaffolds are usually porous and harbor various biomolecules and/or cells. Therefore, current biomedical applications of CaPO4-based bioceramics include artificial bone grafts, bone augmentations, maxillofacial reconstruction, spinal fusion, and periodontal disease repairs, as well as bone fillers after tumor surgery. Prospective future applications comprise drug delivery and tissue engineering purposes because CaPO4 appear to be promising carriers of growth factors, bioactive peptides, and various types of cells.
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页数:89
相关论文
共 975 条
[1]   A simple pathway in preparation of controlled porosity of biphasic calcium phosphate scaffold for dentin regeneration [J].
AbdulQader, Sarah Talib ;
Ab Rahman, Ismail ;
Ismail, Hanafi ;
Kannan, Thirumulu Ponnuraj ;
Mahmood, Zuliani .
CERAMICS INTERNATIONAL, 2013, 39 (03) :2375-2381
[2]   Nanostructure processing of hydroxyapatite-based bioceramics [J].
Ahn, ES ;
Gleason, NJ ;
Nakahira, A ;
Ying, JY .
NANO LETTERS, 2001, 1 (03) :149-153
[3]   Production of highly porous triphasic calcium phosphate scaffolds with excellent in vitro bioactivity using vacuum-assisted foaming of ceramic suspension (VFC) technique [J].
Ahn, Min-Kyung ;
Moon, Young-Wook ;
Koh, Young-Hag ;
Kim, Hyoun-Ee .
CERAMICS INTERNATIONAL, 2013, 39 (05) :5879-5885
[4]   3D plotting of growth factor loaded calcium phosphate cement scaffolds [J].
Akkineni, Ashwini Rahul ;
Luo, Yongxiang ;
Schumacher, Matthias ;
Nies, Berthold ;
Lode, Anja ;
Gelinsky, Michael .
ACTA BIOMATERIALIA, 2015, 27 :264-274
[5]   Porous triphasic calcium phosphate bioceramics [J].
Albuquerque, JSV ;
Nogueira, REFQ ;
da Silva, TDP ;
Lima, DO ;
da Silva, MHP .
BIOCERAMICS 16, 2004, 254-2 :1021-1024
[6]  
alliedmarketresearch, BON GRAFT SUBST MARK
[7]   Fabrication of low temperature macroporous hydroxyapatite scaffolds by foaming and hydrolysis of an α-TCP paste [J].
Almirall, A ;
Larrecq, G ;
Delgado, JA ;
Martínez, S ;
Planell, JA ;
Ginebra, MP .
BIOMATERIALS, 2004, 25 (17) :3671-3680
[8]  
Amjad Z., 1997, Calcium phosphates in biological and industrial systems, P529
[9]  
[Anonymous], 2012, QUAL ACCESS SUCCE S5
[10]  
[Anonymous], 2014, ADV MATER RES-KR, DOI [DOI 10.1007/s10856-009-3980-1, DOI 10.4028/WWW.SCIENTIFIC.NET/AMR.936.687]