Two new tetracyclic triterpenoids from the endophytic fungus Hypoxylon sp. 6269

被引：12

作者：

Liang, Han-Qiao ^{[1
,2
,3
]}

Zhang, Da-Wei ^{[1
,2
,4
]}

Guo, Shun-Xing ^{[1
,2
]}

Yu, Jie ^{[3
]}

机构：

[1] Chinese Acad Med Sci, Inst Med Plant Dev, Minist Educ, Key Lab Bioact Subst & Resource Utilizat Chinese, Beijing 100193, Peoples R China

[2] Peking Union Med Coll, Beijing 100193, Peoples R China

[3] Beijing City Univ, Biomed Sch, Beijing 100094, Peoples R China

[4] Jiangsu Univ Technol, Sch Elect & Informat Engn, Inst Bioinformat & Med Engn, Changzhou 213001, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2018年 / 20卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Endophytic fungus; tetracyclic triterpenoids; Hypoxylon sp; HIV-1; integrase; INTEGRASE; INHIBITION;

D O I：

10.1080/10286020.2018.1485662

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new tetracyclic triterpenoids, integracide E (1) and isointegracide E (2), as well as three known secondary metabolites (i.e. integracide A (3), 2-deoxyintegracide A (4) and 2-deoxyintegracide B (5)), were isolated from mycelium of the endophytic fungus Hypoxylon sp. 6269. Structures were determined by a combination of 1D and 2D NMR techniques and mass spectrometry. All of the compounds were tested for their anti-HIV-1 integrase activities. [GRAPHICS] .

引用

页码：951 / 956

页数：6

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