Limited allelic diversity of stimulatory two-domain killer cell immunoglobulin-like receptors

被引：22

作者：

Hou, Lihua ^{[2
]}

Steiner, Noriko K. ^{[1
]}

Chen, Minghua ^{[2
]}

Belle, Ian

Kubit, Anna L. ^{[1
]}

Ng, Jennifer ^{[2
]}

Hurley, Carolyn Katovich ^{[1
]}

机构：

[1] Georgetown Univ, CW Bill Young Marrow Donor Recruitment & Res Prog, Dept Oncol, Washington, DC 20057 USA

[2] Georgetown Univ, CW Bill Young Marrow Donor Recruitment & Res Prog, Dept Pediat, Washington, DC USA

来源：

HUMAN IMMUNOLOGY | 2008年 / 69卷 / 03期

关键词：

natural killer cell; immune receptor; immunogenetics; killer cell immunoglobulin-like receptor;

D O I：

10.1016/j.humimm.2008.01.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Genomic sequencing was used to characterize most of the coding regions of the five two-domain stimulatory killer cell immunoglobulin-like receptor (KIR) loci from 80 unrelated, primarily Caucasian, individuals. Specific Loci were present in from 26% (KIR2DS3) to 98% (KIR2DS4) of individuals. The number of known alleles present varied from one (KIR2DS1, KIR2DS5) to five (KIR2DS4). The frequencies of Loci and alleles were similar to observations made in populations of European and Asian ethnicities. New alleles were found at 2DS1 (*00202, '00302, *005, *006, *007) and 2DS4 (*008) loci. (c) 2008 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. ALL rights reserved.

引用

页码：174 / 178

页数：5

共 29 条

[1] KIR2DS1-positive NK cells mediate alloresponse against the C2HLA-KIR ligand group in vitro [J].