Synthesis of new azo dye compounds derived from 2-aminobenzothiazole and study their biological activity

In this work, new 2-amino benzothiazole (W1) were synthesized from the reaction between aniline substituted with potassium thiocyanate in presence of broom. (W1) reaction with phenol substituted to give azo dyes compound (W2-W5). Polyacrylic acid was converted into poly acryloyl chloride by reaction poly acrylic acid with thionyl chloride was dissolved in acetonitrile with reaction different organic compounds. (W1-9) characterized were using (IR) and (HNMR-CNMR-CHN-TLC) techniques and the analysis revealed biological activity for chemical compounds at three concentrations (0.01, 0.001, 0.0001) mg/ml. (MIC) was calculated using standard drugs as a comparison. The findings revealed that azo derivatives outperformed medication in inhibiting the growth of gram negative & positive bacteria. (c) 2021 Elsevier Ltd. All rights reserved. Selection and peer-review under responsibility of the scientific committee of the Technology Innovation in Mechanical Engineering-2021.