An 8-aminoimidazo[4,5-g]quinazoline carbocyclic nucleoside:: a ring-extended analog of 5′-noraristeromycin

被引：8

作者：

Rajappan, VP ^{[1
]}

Schneller, SW ^{[1
]}

机构：

[1] Auburn Univ, Dept Chem, Auburn, AL 36849 USA

来源：

TETRAHEDRON | 2001年 / 57卷 / 44期

关键词：

purines; nucleosides; polycyclic heterocyclic compounds; antiviral;

D O I：

10.1016/S0040-4020(01)00909-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The antiviral properties of 5 ' -noraristeromycin (3) have been attributed to its inhibition of S-adenosylhomocysteine hydrolase. As part of an effort to establish the limiting structural parameters possible for the biological properties of 3, a ring-extended analog possessing 8-aminoimidazo[4,5-g]quinazoline as the base (7) has been prepared and found to be less active than 3. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：9049 / 9053

页数：5

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