Inhibition of metastasis by a dialysable factor in fetal bovine serum in B16 melanoma cells

被引：4
|
作者：
Ota, T [1 ]
Maeda, M [1 ]
Matsui, T [1 ]
Kohno, H [1 ]
Tanino, M [1 ]
Odashima, S [1 ]
机构：
[1] KANAZAWA MED UNIV,DEPT ORAL SURG,UCHINADA,ISHIKAWA 92002,JAPAN
来源：
CANCER LETTERS | 1996年 / 110卷 / 1-2期
关键词：
metastasis; fetal bovine serum; B16 melanoma cells;
D O I：
10.1016/S0304-3835(96)04496-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Fetal bovine serum (FBS) supplemented to the culture medium inhibited the metastasis of B16BL6 melanoma cells in a dose-dependent manner. This metastasis-inhibiting activity was accompanied by growth-promoting activity, up to the concentration of 10% FBS, However, among the clones isolated from B16BL6 cells, there were clones in which FBS significantly inhibited the metastasis without promoting their growth. Dialysis (cutoff M.W, 8000 Da) removed the metastasis-inhibiting activity but not the growth-promoting activity from FBS. These results indicate that FBS has metastasis-inhibiting activity which is independent of growth-promoting activity, and that the metastasis-inhibiting activity is carried by molecules removed by dialysis.
引用
收藏
页码：201 / 205
页数：5
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