In Silico Drug Screen in Mouse Liver Identifies Candidate Calorie Restriction Mimetics

被引：8

作者：

Fortney, Kristen ^{[1
]}

Morgen, Eric K. ^{[2
,4
]}

Kotlyar, Max ^{[1
]}

Jurisica, Igor ^{[1
,3
,5
]}

机构：

[1] Univ Toronto, Dept Med Biophys, Toronto, ON M5S 1A1, Canada

[2] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A1, Canada

[3] Univ Toronto, Dept Comp Sci, Toronto, ON M5S 1A1, Canada

[4] Univ Hlth Network, Dept Pathol, Toronto, ON, Canada

[5] Univ Hlth Network, Ontario Canc Inst, Toronto, ON, Canada

来源：

REJUVENATION RESEARCH | 2012年 / 15卷 / 02期

基金：

加拿大创新基金会;

关键词：

GENE-EXPRESSION; RESPONSES; MICE;

D O I：

10.1089/rej.2011.1263

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Calorie restriction (CR) extends life span in mammals and delays the onset of age-related diseases, including cancer and diabetes. Drugs that target the same genes and pathways as CR may have enormous therapeutic potential. Recently, genome-scale data on the responses of human cell lines to over 1,000 drug treatments have become available. Here we integrate these data with gene expression signatures of CR in mouse liver to generate a prioritized list of candidate CR mimetics. We identify 14 drugs that reproduce the effects of CR at the transcriptional level.

引用

页码：148 / 152

页数：5

共 6 条

[1] Deep sequencing identifies circulating mouse miRNAs that are functionally implicated in manifestations of aging and responsive to calorie restriction
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AGING-US, 2013, 5 (02): : 130 - 141
[2] Effects of endurance training under calorie restriction on energy substrate metabolism in mouse skeletal muscle and liver
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[3] Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer's disease
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[4] The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice
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[5] A High-Throughput In Vitro Drug Screen in a Genetically Engineered Mouse Model of Diffuse Intrinsic Pontine Glioma Identifies BMS-754807 as a Promising Therapeutic Agent
Halvorson, Kyle G.
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PLOS ONE, 2015, 10 (03):
[6] Deep short-read sequencing of chromosome 17 from the mouse strains A/J and CAST/Ei identifies significant germline variation and candidate genes that regulate liver triglyceride levels
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GENOME BIOLOGY, 2009, 10 (10):

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