Epigenetic modifications working in the decidualization and endometrial receptivity

被引:71
作者
Liu, Hong [1 ]
Huang, Xiaobo [1 ]
Mor, Gil [1 ,2 ]
Liao, Aihua [1 ]
机构
[1] Huazhong Univ Sci & Technol, Inst Reprod Hlth, Ctr Reprod Med, Tongji Med Coll, 13 Hangkong Rd, Wuhan 430030, Peoples R China
[2] Wayne State Univ, Dept Obstet & Gynecol, CS Mott Ctr Human Growth & Dev, Detroit, MI USA
基金
中国国家自然科学基金;
关键词
Decidualization; DNA methylation; Histone modification; Non-coding RNAs; Human endometrial stromal cells; LONG NONCODING RNAS; COMPETING ENDOGENOUS RNA; DNA METHYLTRANSFERASES; STROMAL CELLS; IMPLANTATION FAILURE; PROLACTIN PRODUCTION; HISTONE ACETYLATION; IGFBP-1; EXPRESSION; EARLY-PREGNANCY; DOWN-REGULATION;
D O I
10.1007/s00018-019-03395-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Decidualization is a critical event for the blastocyst implantation, placental development and fetal growth and the normal term. In mice, the embryo implantation to the uterine epithelial would trigger the endometrial stromal cells to differentiate into decidual stromal cells. However, decidualization in women takes place from the secretory phase of each menstrual cycle and continues to early pregnancy if there is conceptus. Deficient decidualization is often associated with pregnancy specific complications and reproductive disorders. Dramatic changes occur in the gene expression profiles during decidualization, which is coordinately regulated by steroid hormones, growth factors, and molecular and epigenetic mechanisms. Recently, emerging evidences showed that epigenetic modifications, mainly including DNA methylation, histone modification, and non-coding RNAs, play an important role in the decidualization process via affecting the target genes' expression. In this review, we will focus on the epigenetic modifications in decidualization and open novel avenues to predict and treat the pregnancy complications caused by abnormal decidualization.
引用
收藏
页码:2091 / 2101
页数:11
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