Diagnosis and treatment of anti-myelin oligodendrocyte glycoprotein antibody positive optic neuritis

被引：39

作者：

Kezuka, Takeshi ^{[1
,2
]}

Ishikawa, Hitoshi ^{[3
]}

机构：

[1] KEZUKA Eye Clin, Sumida Ku, 1-5-7 Mukojima, Tokyo 1310033, Japan

[2] Tokyo Med Univ, Dept Ophthalmol, Tokyo, Japan

[3] Kitasato Univ, Sch Allied Hlth Sci, Dept Orthopt & Visual Sci, Sagamihara, Kanagawa, Japan

来源：

JAPANESE JOURNAL OF OPHTHALMOLOGY | 2018年 / 62卷 / 02期

关键词：

Anti-myelin oligodendrocyte glycoprotein antibody; Anti-MOG antibody; Optic neuritis; Chronic recurrent inflammatory optic neuropathy; NMO SPECTRUM DISORDERS; NEUROMYELITIS-OPTICA; MOG ANTIBODY; TREATMENT TRIAL; MULTICENTER; ENCEPHALOMYELITIS; AUTOANTIBODY; DISTINCTION; FEATURES; MOUSE;

D O I：

10.1007/s10384-018-0561-1

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Anti-myelin-oligodendrocyte glycoprotein (MOG) antibody positive optic neuritis has been established as a new subset of optic neuropathy. Anti-MOG antibodies are usually measured by cell-based assay. Patients with anti-MOG antibody positive optic neuritis respond well to steroid therapy, and, while visual acuity outcomes are favorable, significant visual field defects remain. Furthermore, patients who are anti-MOG antibody positive have higher rates of recurrence compared to antibody negative patients. Based on these findings, anti-MOG antibody positive patients with optic neuritis have the characteristics of good visual outcomes, residual visual field defects, and high risk of recurrence. Tests for anti-MOG antibody are useful for the diagnosis and treatment of optic neuritis.

引用

页码：101 / 108

页数：8

共 32 条

[1] Lesion length of optic neuritis impacts visual prognosis in neuromyelitis optica [J].

Akaishi, Tetsuya ;

Nakashima, Ichiro ;

Takeshita, Takayuki ;

Mugikura, Shunji ;

Sato, Douglas Kazutoshi ;

Takahashi, Toshiyuki ;

Nishiyama, Shuhei ;

Kurosawa, Kazuhiro ;

Misu, Tatsuro ;

Nakazawa, Toru ;

Aoki, Masashi ;

Fujihara, Kazuo .

JOURNAL OF NEUROIMMUNOLOGY, 2016, 293 :28-33

[2] MRI and retinal abnormalities in isolated optic neuritis with myelin oligodendrocyte glycoprotein and aquaporin-4 antibodies: a comparative study [J].

Akaishi, Tetsuya ;

Sato, Douglas Kazutoshi ;

Nakashima, Ichiro ;

Takeshita, Takayuki ;

Takahashi, Toshiyuki ;

Doi, Hiroshi ;

Kurosawa, Kazuhiro ;

Kaneko, Kimihiko ;

Kuroda, Hiroshi ;

Nishiyama, Shuhei ;

Misu, Tatsuro ;

Nakazawa, Toru ;

Fujihara, Kazuo ;

Aoki, Masashi .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2016, 87 (04) :446-+

[3]

Baumann M, 2015, J NEUROL NEUROSUR PS, V86, P7

[4] THE CLINICAL PROFILE OF OPTIC NEURITIS - EXPERIENCE OF THE OPTIC NEURITIS TREATMENT TRIAL [J].

BECH, RW .

ARCHIVES OF OPHTHALMOLOGY, 1991, 109 (12) :1673-1678

[5] ANTI-MOG ANTIBODIES ARE FREQUENTLY ASSOCIATED WITH STEROID-SENSITIVE RECURRENT OPTIC NEURITIS [J].

Chalmoukou, Konstantina ;

Alexopoulos, Harry ;

Akrivou, Sofia ;

Stathopoulos, Panos ;

Reindl, Markus ;

Dalakas, Marinas C. .

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 2015, 2 (04)

[6]

DEROSBO NK, 1990, J NEUROCHEM, V55, P583

[7]

Goseki T., 2017, RINSHO GANKA, V71, P1688

[8] Autoantibody biomarkers in childhood-acquired demyelinating syndromes: results from a national surveillance cohort [J].

Hacohen, Yael ;

Absoud, Michael ;

Woodhall, Mark ;

Cummins, Carole ;

De Goede, Christian G. ;

Hemingway, Cheryl ;

Jardine, Philip E. ;

Kneen, Rachel ;

Pike, Michael G. ;

Whitehouse, William P. ;

Wassmer, Evangeline ;

Waters, Patrick ;

Vincent, Angela ;

Lim, Ming .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2014, 85 (04) :456-461

[9] Increased interleukin-6 correlates with myelin oligodendrocyte glycoprotein antibodies in pediatric monophasic demyelinating diseases and multiple sclerosis [J].

Horellou, Philippe ;

Wang, Min ;

Keo, Vixra ;

Chretien, Pascale ;

Serguera, Che ;

Waters, Patrick ;

Deiva, Kumaran .

JOURNAL OF NEUROIMMUNOLOGY, 2015, 289 :1-7

[10] MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome [J].

Jarius, Sven ;

Ruprecht, Klemens ;

Kleiter, Ingo ;

Borisow, Nadja ;

Asgari, Nasrin ;

Pitarokoili, Kalliopi ;

Pache, Florence ;

Stich, Oliver ;

Beume, Lena-Alexandra ;

Huemmert, Martin W. ;

Ringelstein, Marius ;

Trebst, Corinna ;

Winkelmann, Alexander ;

Schwarz, Alexander ;

Buttmann, Mathias ;

Zimmermann, Hanna ;

Kuchling, Joseph ;

Franciotta, Diego ;

Capobianco, Marco ;

Siebert, Eberhard ;

Lukas, Carsten ;

Korporal-Kuhnke, Mirjam ;

Haas, Juergen ;

Fechner, Kai ;

Brandt, Alexander U. ;

Schanda, Kathrin ;

Aktas, Orhan ;

Paul, Friedemann ;

Reindl, Markus ;

Wildemann, Brigitte .

JOURNAL OF NEUROINFLAMMATION, 2016, 13

← 1 2 3 4 →