New lines of host defense: inhibition of Ty1 retrotransposition by Fus3p and NER/TFIIH

被引：42

作者：

Curcio, MJ

Garfinkel, DJ

机构：

[1] SUNY Albany, Sch Publ Hlth, Wadsworth Ctr, Mol Genet Program, Albany, NY 12201 USA

[2] NCI, Frederick Canc Res & Dev Ctr, Movable Genet Elements Sect, Gene Regulat & Chromosome Biol Lab,ABL Basic Res, Frederick, MD 21702 USA

来源：

TRENDS IN GENETICS | 1999年 / 15卷 / 02期

关键词：

D O I：

10.1016/S0168-9525(98)01643-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The genomes of all organisms examined contain transposons whose uncontrolled movement threatens genome function. Fortunately, host cells have evolved defense mechanisms to minimize the level of transposition. In this review we discuss recent work showing that proteins involved in signal transduction and RNA transcription/DNA repair inhibit Ty1 retrotransposition in the yeast Saccharomyces cerevisiae. On the basis of these examples, we hypothesize that the level of Ty1 retrotransposition may be modulated in response to environmental stress signals that affect cellular differentiation and DNA repair.

引用

页码：43 / 45

页数：5

共 19 条

[1]

BAILIS AM, 1995, MOL CELL BIOL, V15, P3998

[2] Positional cloning of the mouse retrovirus restriction gene Fv1 [J].