Red-shifted optogenetic excitation:: a tool for fast neural control derived from Volvox carteri

被引：396

作者：

Zhang, Feng ^{[2
,3
]}

Prigge, Matthias ^{[1
]}

Beyriere, Florent ^{[1
]}

Tsunoda, Satoshi P. ^{[1
]}

Mattis, Joanna ^{[2
,3
]}

Yizhar, Ofer ^{[2
,3
]}

Hegemann, Peter ^{[1
]}

Deisseroth, Karl ^{[2
,3
]}

机构：

[1] Humboldt Univ, Inst Biol Expt Biophys, D-10115 Berlin, Germany

[2] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Psychiat, Stanford, CA 94305 USA

来源：

NATURE NEUROSCIENCE | 2008年 / 11卷 / 06期

关键词：

D O I：

10.1038/nn.2120

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The introduction of two microbial opsin- based tools, channelrhodopsin-2 (ChR2) and halorhodopsin (NpHR), to neuroscience has generated interest in fast, multimodal, cell type-specific neural circuit control. Here we describe a cation-conducting channelrhodopsin (VChR1) from Volvox carteri that can drive spiking at 589 nm, with excitation maximum red-shifted similar to 70 nm compared with ChR2. These results demonstrate fast photostimulation with yellow light, thereby defining a functionally distinct third category of microbial rhodopsin proteins.

引用

页码：631 / 633

页数：3

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