Silk sericin as a biomaterial for tissue engineering: a review

被引:72
作者
Arango, Maria C. [1 ]
Montoya, Yuliet [2 ]
Peresin, Maria S. [3 ]
Bustamante, John [2 ]
alvarez-Lopez, Catalina [1 ]
机构
[1] Univ Pontificia Bolivariana, Fac Ingn Agroind, Grp Invest Agroind, Medellin, Colombia
[2] Univ Pontificia Bolivariana, Grp Dinam Cardiovasc, Escuela Ciencias Salud, Medellin, Colombia
[3] Auburn Univ, Sch Forestry & Wildlife Sci, Forest Prod Dev Ctr, Auburn, AL 36849 USA
关键词
Biocompatibility; biomaterial; silk sericin; tissue engineering; wound healing; BACTERIAL CELLULOSE; IN-VIVO; PROTEIN SERICIN; SCAFFOLDS; EXTRACTION; COLLAGEN; MEMBRANES; EFFICACY; SAFETY; VITRO;
D O I
10.1080/00914037.2020.1785454
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Silk sericin is a natural polymer produced by silkwormBombyx mori; which has the function of covering the fibroin filaments so that they remain linked together as well as maintaining the structural integrity of the cocoon. Despite its properties and benefits, sericin is currently discarded during textile production as it is considered a side product of silk cocoons during the degumming process. Among the most important biological properties of sericin are good oxygen permeability, moisture-regulating capacity, resistance to UV radiation, ability to promotes cell growth, biocompatibility and mitogenic effect. All these characteristics make sericin a promising polymer to be used in biomedical applications, especially in tissue engineering and regenerative medicine. Some studies report that sericin favors the biological nature of keratinocytes and fibroblasts, potentializing it as a biomaterial for the repair of epithelial tissue, mainly utilized as wound dressing. Given the importance that sericin can have in the field of bioengineering, and that its use can favor the sericulture agroindustry, this manuscript reviews recent studies of this protein for its application in tissue engineering, specifically for cutaneous regeneration.
引用
收藏
页码:1115 / 1129
页数:15
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