Paul Ehrlich's magic bullet concept: 100 years of progress

被引：952
作者：
Strebhardt, Klaus [1 ]
Ullrich, Axel [2 ]
机构：
[1] Univ Frankfurt Klinikum, Sch Med, Dept Obstet & Gynaecol, D-60590 Frankfurt, Germany
[2] Max Planck Inst Biochem, Dept Mol Biol, D-82152 Martinsried, Germany
来源：
NATURE REVIEWS CANCER | 2008年 / 8卷 / 06期
关键词：
D O I：
10.1038/nrc2394
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Exceptional advances in molecular biology and genetic research have expedited cancer drug development tremendously. The declared paradigm is the development of 'personalized and tailored drugs' that precisely target the specific molecular defects of a cancer patient. it is therefore appropriate to revisit the intellectual foundations of the development of such agents, as many have shown great clinical success. One hundred years ago, Paul Ehrlich, the founder of chemotherapy, received the Nobel Prize for Physiology or Medicine. His postulate of creating 'magic bullets' for use in the fight against human diseases inspired generations of scientists to devise powerful molecular cancer therapeutics.
引用
收藏
页码：473 / 480
页数：8
相关论文
共 162 条
[51]  
Espina Virginia, 2007, V383, P321, DOI 10.1007/978-1-59745-335-6_21
[52]   Molecular basis for sunitinib efficacy and future clinical development [J].
Faivre, Sandrine ;
Demetri, George ;
Sargent, William ;
Raymond, Eric .
NATURE REVIEWS DRUG DISCOVERY, 2007, 6 (09) :734-745
[53]   TEMPORARY REMISSIONS IN ACUTE LEUKEMIA IN CHILDREN PRODUCED BY FOLIC ACID ANTAGONIST, 4-AMINOPTEROYL-GLUTAMIC ACID (AMINOPTERIN) [J].
FARBER, S ;
DIAMOND, LK ;
MERCER, RD ;
SYLVESTER, RF ;
WOLFF, JA .
NEW ENGLAND JOURNAL OF MEDICINE, 1948, 238 (23) :787-793
[54]   Cancer revoked: oncogenes as therapeutic targets [J].
Felsher, DW .
NATURE REVIEWS CANCER, 2003, 3 (05) :375-380
[55]   Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors [J].
Finnin M.S. ;
Donigian J.R. ;
Cohen A. ;
Richon V.M. ;
Rifkind R.A. ;
Marks P.A. ;
Breslow R. ;
Pavletich N.P. .
Nature, 1999, 401 (6749) :188-193
[56]   THE MORPHOLOGY AND MOTILITY OF PROTEUS-VULGARIS AND OTHER ORGANISMS CULTURED IN THE PRESENCE OF PENICILLIN [J].
FLEMING, A ;
VOUREKA, A ;
KRAMER, IRH ;
HUGHES, WH .
JOURNAL OF GENERAL MICROBIOLOGY, 1950, 4 (02) :257-&
[57]  
Fong TAT, 1999, CANCER RES, V59, P99
[58]  
FREI E, 1966, CANCER RES, V26, P1284
[59]   A COMPARATIVE STUDY OF 2 REGIMENS OF COMBINATION CHEMOTHERAPY IN ACUTE LEUKEMIA [J].
FREI, E ;
HOLLAND, JF ;
SCHNEIDERMAN, MA ;
PINKEL, D ;
SELKIRK, G ;
FREIREICH, EJ ;
SILVER, RT ;
GOLD, GL ;
REGELSON, W .
BLOOD, 1958, 13 (12) :1126-1148
[60]  
FREI EMIL, 1966, CANCER CHEMOTHERAP REP, V50, P1
12345678910