Paul Ehrlich's magic bullet concept: 100 years of progress

被引：924
作者：
Strebhardt, Klaus [1 ]
Ullrich, Axel [2 ]
机构：
[1] Univ Frankfurt Klinikum, Sch Med, Dept Obstet & Gynaecol, D-60590 Frankfurt, Germany
[2] Max Planck Inst Biochem, Dept Mol Biol, D-82152 Martinsried, Germany
来源：
NATURE REVIEWS CANCER | 2008年 / 8卷 / 06期
关键词：
D O I：
10.1038/nrc2394
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Exceptional advances in molecular biology and genetic research have expedited cancer drug development tremendously. The declared paradigm is the development of 'personalized and tailored drugs' that precisely target the specific molecular defects of a cancer patient. it is therefore appropriate to revisit the intellectual foundations of the development of such agents, as many have shown great clinical success. One hundred years ago, Paul Ehrlich, the founder of chemotherapy, received the Nobel Prize for Physiology or Medicine. His postulate of creating 'magic bullets' for use in the fight against human diseases inspired generations of scientists to devise powerful molecular cancer therapeutics.
引用
收藏
页码：473 / 480
页数：8
相关论文
共 162 条
  • [31] Protein crystallization: virtual screening and optimization
    DeLucas, LJ
    Hamrick, D
    Cosenza, L
    Nagy, L
    McCombs, D
    Bray, T
    Chait, A
    Stoops, B
    Belgovskiy, A
    Wilson, WW
    Parham, M
    Chernov, N
    [J]. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2005, 88 (03) : 285 - 309
  • [32] Complement activation determines the therapeutic activity of rituximab in vivo
    Di Gaetano, N
    Cittera, E
    Nota, R
    Vecchi, A
    Grieco, V
    Scanziani, E
    Botto, M
    Introna, M
    Golay, J
    [J]. JOURNAL OF IMMUNOLOGY, 2003, 171 (03) : 1581 - 1587
  • [33] Comprehensive survey of combinatorial library synthesis: 1999
    Dolle, RE
    [J]. JOURNAL OF COMBINATORIAL CHEMISTRY, 2000, 2 (05): : 383 - 433
  • [34] Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    Druker, BJ
    Tamura, S
    Buchdunger, E
    Ohno, S
    Segal, GM
    Fanning, S
    Zimmermann, J
    Lydon, NB
    [J]. NATURE MEDICINE, 1996, 2 (05) : 561 - 566
  • [35] Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
    Druker, Brian J.
    Guilhot, Francois
    O'Brien, Stephen G.
    Gathmann, Insa
    Kantarjian, Hagop
    Gattermann, Norbert
    Deininger, Michael W. N.
    Silver, Richard T.
    Goldman, John M.
    Stone, Richard M.
    Cervantes, Francisco
    Hochhaus, Andreas
    Powell, Bayard L.
    Gabrilove, Janice L.
    Rousselot, Philippe
    Reiffers, Josy
    Cornelissen, Jan J.
    Hughes, Timothy
    Agis, Hermine
    Fischer, Thomas
    Verhoef, Gregor
    Shepherd, John
    Saglio, Giuseppe
    Gratwohl, Alois
    Nielsen, Johan L.
    Radich, Jerald P.
    Simonsson, Bengt
    Taylor, Kerry
    Baccarani, Michele
    So, Charlene
    Letvak, Laurie
    Larson, Richard A.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (23) : 2408 - 2417
  • [36] On the present state of chemotherapy.
    Ehrlich, P
    [J]. BERICHTE DER DEUTSCHEN CHEMISCHEN GESELLSCHAFT, 1909, 42 : 17 - 47
  • [37] EHRLICH P, 1902, SEITENKETTENTHEORIE, V3, P381
  • [38] Ehrlich P., 1911, FOLIA SEROLOGICA, V7, P697
  • [39] Ehrlich P., 1900, P R SOC LONDON, V66, P424, DOI 10.1098/rspl.1899.0121
  • [40] Ehrlich P., 1909, Beitrage zur experimentellen Pathologie und Chemotherapie, P117
12345678910