Paul Ehrlich's magic bullet concept: 100 years of progress

被引：958

作者：

Strebhardt, Klaus ^{[1
]}

Ullrich, Axel ^{[2
]}

机构：

[1] Univ Frankfurt Klinikum, Sch Med, Dept Obstet & Gynaecol, D-60590 Frankfurt, Germany

[2] Max Planck Inst Biochem, Dept Mol Biol, D-82152 Martinsried, Germany

来源：

NATURE REVIEWS CANCER | 2008年 / 8卷 / 06期

关键词：

D O I：

10.1038/nrc2394

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Exceptional advances in molecular biology and genetic research have expedited cancer drug development tremendously. The declared paradigm is the development of 'personalized and tailored drugs' that precisely target the specific molecular defects of a cancer patient. it is therefore appropriate to revisit the intellectual foundations of the development of such agents, as many have shown great clinical success. One hundred years ago, Paul Ehrlich, the founder of chemotherapy, received the Nobel Prize for Physiology or Medicine. His postulate of creating 'magic bullets' for use in the fight against human diseases inspired generations of scientists to devise powerful molecular cancer therapeutics.

引用

页码：473 / 480

页数：8

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