PGD-derived human embryonic stem cell lines as a powerful tool for the study of human genetic disorders

被引：36

作者：

Ben-Yosef, D. ^{[1
]}

Malcov, M. ^{[1
]}

Eiges, R. ^{[2
]}

机构：

[1] Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Racine IVF Unit,Lis Matern Hosp, IL-64239 Tel Aviv, Israel

[2] Hebrew Univ Jerusalem, Dept Genet, Alexander Silberman Inst Life Sci, IL-91904 Jerusalem, Israel

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2008年 / 282卷 / 1-2期

关键词：

human embryonic stem cells; preimplantation genetic diagnosis (PGD); genetic disorders;

D O I：

10.1016/j.mce.2007.11.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Human embryonic stem (ES) cells are derived from the inner cell mass (ICM) of blastocyst embryos. They are established from spare embryos that have been obtained by in vitro fertilization (IVF) and donated for research purposes. The ICM-derived cell lines have two unique properties, they can be propagated indefinitely in culture and have the potential to develop into practically any cell type in vitro and in vivo. Human embryonic stem (hES) cells carrying specific mutations can be used as a valuable tool for studying genetic disorders in human. One favorable approach to obtain such mutant ES cell lines is their derivation from affected preimplantation genetic diagnosed (PGD) embryos. This review focuses on the importance of deriving human ES cell lines from genetically abnormal embryos, especially in cases where no good cellular and/or animal models exist. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：153 / 158

页数：6

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