Novel 3-pyridinecarbonitriles incorporating sulfonamide moieties as anti-breast cancer agents

被引：3

作者：

Ghorab, Mostafa M. ^{[1
,2
]}

Alsaid, Mansour S. ^{[1
]}

机构：

[1] King Saud Univ, Dept Pharmacognosy, Coll Pharm, POB 2457, Riyadh 11451, Saudi Arabia

[2] Natl Ctr Radiat Res & Technol, Dept Drug Radiat Res, Cairo 113701, Egypt

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2016年 / 42卷 / 04期

关键词：

synthesis; 3-pyridinecarbonitrile; sulfonamide; anti-breast cancer activity; CARBONIC-ANHYDRASE INHIBITORS; MOLECULAR DOCKING; ANTICANCER ACTIVITY; PYRROLOPYRIMIDINE; DERIVATIVES; PYRROLE; POTENT; 2-(3-FLUORO-4-METHYLSULFONYLAMINOPHENYL)PROPANAMIDES;

D O I：

10.1134/S1068162016040087

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel series of 3-pyridinecarbonitrile derivatives incorporating sulfonamide moieties and sulfonyl derivatives was synthesized using 2-chloro-6-methylnicotinonitrile as a strategic starting material. The structures of the synthesized compounds were elucidated on the basis of elemental analysis, IR, H-1 NMR, C-13 NMR, and mass spectral data. All the prepared compounds were evaluated for their in vitro anticancer activity against breast cancer cell line (MCF-7). Most of the compounds showed good to moderate activity, higher than that of the reference drug doxorubicin. Two compounds showed the same activity as doxorubicin, while three compounds exhibited remarkable activity.

引用

页码：441 / 448

页数：8

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