Leptin-deficient mice are protected from accelerated nephrotoxic nephritis

被引：46

作者：

Tarzi, RM

Cook, HT

Jackson, I

Pusey, CD

Lord, GM

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Fac Med, Dept Renal Med & Transplantat, London, England

[2] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Fac Med, Dept Histopathol, London, England

[3] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Fac Med, Dept Immunol, London, England

来源：

AMERICAN JOURNAL OF PATHOLOGY | 2004年 / 164卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0002-9440(10)63128-8

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Leptin is an adipose tissue-derived hormone that signals nutritional status to the hypothalamus. Recent evidence indicates that leptin modifies proinflammatory immune responses and may provide a key link between nutritional deficiency and immune dysfunction. To study the influence of leptin deficiency on immune-mediated renal disease, susceptibility to accelerated nephrotoxic nephritis was examined in leptin-deficient C57BL/6-ob/ob mice and C57BL/6 wildtype controls. The model was induced with sheep anti-mouse glomerular basement membrane antibody injected to mice preimmunized against sheep IgG, and mice were sacrificed 8 days after induction of disease. The leptin-deficient ob/ob mice were strongly protected from glomerular crescent formation, macrophage infiltration, glomerular thrombosis, and albuminuria in this model. Our findings suggest that leptin is required for the induction and maintenance of immune-mediated glomerulonephritis, and that blockade of the leptin axis might provide an attractive therapeutic possibility in human autoimmune disease.

引用

页码：385 / 390

页数：6

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