The prognostic value of organ/space surgical site infection in stage I colorectal cancer recurrence

被引：9

作者：

Akabane, Shintaro ^{[1
]}

Egi, Hiroyuki ^{[1
]}

Takakura, Yuji ^{[1
]}

Sada, Haruki ^{[2
,3
]}

Kochi, Masatoshi ^{[1
]}

Taguchi, Kazuhiro ^{[1
]}

Nakashima, Ikki ^{[1
]}

Sumi, Yusuke ^{[1
]}

Sato, Koki ^{[1
]}

Yoshinaka, Hisaaki ^{[1
]}

Hattori, Minoru ^{[4
]}

Ohdan, Hideki ^{[1
]}

机构：

[1] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Gastroenterol & Transplant Surg, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan

[2] Natl Hosp Org, Kum Med Ctr, Dept Surg, Kure, Hiroshima, Japan

[3] Chugoku Canc Ctr, Kure, Hiroshima, Japan

[4] Hiroshima Univ, Ctr Med Educ, Sch Med, Higashihiroshima, Hiroshima, Japan

来源：

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE | 2020年 / 35卷 / 09期

关键词：

Colorectal cancer; Stage I; Organ; space surgical site infection; Postoperative recurrence; RISK-FACTORS; CURATIVE RESECTION; ANASTOMOTIC LEAK; RECTAL-CANCER; COLON-CANCER; MORTALITY; TRANSFUSION; SURVIVAL; SURGERY; IMPACT;

D O I：

10.1007/s00384-020-03643-6

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Purpose Evidence on risk factors for postoperative recurrence in patients with colorectal cancer (CRC) confined to pathological stage I is limited. Therefore, this study aimed to identify the risk factors for recurrence in patients with stage I CRC. Methods Data on clinicopathological factors and blood tests of patients diagnosed with pathological stage I CRC at Hiroshima University Hospital between April 1, 2010, and December 31, 2018, were retrospectively obtained. The statistical significance between the clinical factors and postoperative recurrence was also investigated. Results A total of 244 patients were included. The median observation period was 45 months. There were 17 patients (6.6%) with a postoperative recurrence (8 local and 9 distant recurrences). In the log-lank test, rectal cancer (p = 0.004), pT2 (p = 0.020) and organ/space surgical site infection (SSI) (p = 0.008) were significantly associated with postoperative recurrence. In a multivariate analysis, rectal cancer (hazard ratio [HR] 3.678, 95% confidence interval [CI] 1.184-11.425, p = 0.024) and organ/space SSI (HR 3.137, 95% CI 1.013-9.713, p = 0.047) were independently associated with a higher recurrence rate. Among 18 patients with organ/space SSI, 4 recurrences occurred, all of which were distant metastases. Conclusion Organ/space SSI significantly affects the postoperative recurrence in patients with stage I CRC.

引用

页码：1689 / 1694

页数：6

共 21 条

[1] Infectious Postoperative Complications Decrease Long-term Survival in Patients Undergoing Curative Surgery for Colorectal Cancer A Study of 12,075 Patients [J].