Attenuation of morphine withdrawal signs by a D1 receptor agonist in the locus coeruleus of rats

被引：20
作者：
Dizgah, IM
Karimian, SM
Zarrindast, MR
Sohanaki, H
机构：
[1] Univ Tehran Med Sci, Dept Physiol, Sch Med, Tehran, Iran
[2] Univ Tehran Med Sci, Dept Pharmacol, Sch Med, Tehran, Iran
来源：
NEUROREPORT | 2005年 / 16卷 / 15期
关键词：
locus coeruleus; morphine; naloxone; rat; SCH23390; SKF38393; withdrawal;
D O I：
10.1097/01.wnr.0000180142.91644.65
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In the present study, the effects of intra-locus coeruleus injection of a dopamine D(1) receptor agonist (SKF38393) on naloxone-induced withdrawal signs of morphine-dependent rats were examined. Twenty different withdrawal signs were assessed. The total withdrawal score was calculated and used as an index of withdrawal intensity for comparison. The D(1) agonist and antagonist were injected 15 and 30 min prior to expression of naloxone-induced withdrawal signs, respectively. SKF38393 (2 and 4 mu g/site) decreased while SCH23390 (a D(1) antagonist) had no effect on the total withdrawal score. On the other hand, SCH23390 (25 ng/site) reversed the SKF38393 effect. It may be concluded that activation of dopamine D(1) receptors in the locus coeruleus attenuates naloxone-induced withdrawal.
引用
收藏
页码：1683 / 1686
页数：4
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