V1a receptor knockout mice exhibit impairment of spatial memory in an eight-arm radial maze

被引：56

作者：

Egashira, N

Tanoue, A

Higashihara, F

Mishima, K

Fukue, Y

Takano, Y

Tsujimoto, G

Iwasaki, K

Fujiwara, M

机构：

[1] Fukuoka Univ, Fac Pharmaceut Sci, Dept Neuropharmacol, Jonan Ku, Fukuoka 8140180, Japan

[2] Natl Res Inst Child Hlth & Dev, Dept Mol, Setagaya Ku, Tokyo 1548567, Japan

[3] Fukuoka Univ, Fac Pharmaceut Sci, Dept Pharmacol, Jonan Ku, Fukuoka 8140180, Japan

[4] Kyoto Univ, Fac Pharmaceut Sci, Grad Sch Pharmaceut Sci, Dept Genom Drug Discovery Sci,Sakyo Ku, Kyoto 6068501, Japan

来源：

NEUROSCIENCE LETTERS | 2004年 / 356卷 / 03期

关键词：

vasopressin V1a receptor; vasopressin V1b receptor; spatial memory; eight-arm radial maze; knockout mice; OPC-21268;

D O I：

10.1016/j.neulet.2003.11.050

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

in this study, we examined the performance of vasopressin V1a receptor (V1aR) and vasopressin V1b receptor (V1bR) knockout (KO) mice compared to wild-type (WT) mice in an eight-ann radial maze. V1aR KO mice exhibited an impairment of spatial memory in comparison to WT mice. By contrast, we did not observe any significant differences between the V1bR KO mice and the WT mice in the eight-arm radial maze. Moreover, OPC-21268, a selective V1aR antagonist, impaired spatial memory in the eight-ann radial maze in WT mice characterized by an increased number of errors. These results suggest that the V1aR controls spatial memory in mice. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：195 / 198

页数：4