Recent Advances in Chemistry and Biological Activity of 2,6-Diphenyl Piperidines

被引：4
作者：
Yousif, Mahmoud N. M. [1 ]
机构：
[1] Natl Res Ctr, Photochem Dept, Cairo, Egypt
来源：
MINI-REVIEWS IN ORGANIC CHEMISTRY | 2022年 / 19卷 / 01期
关键词：
2,6-Diphenyl-piperidin-4-one; piperidine; biological activity; conformations; synthesis; applications; CONFORMATIONAL-ANALYSIS; STEREOCHEMISTRY; ANTIBACTERIAL; DERIVATIVES;
D O I：
10.2174/1570193X18666210224153249
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The review discusses different methods for the preparation of 2,6-diphenyl-piperidin-4-one derivatives. 2,6-Diphenyl-piperidin-4-one is prepared from aromatic aldehyde and acetone in ammonium acetate. Reaction of 1-phenylsulfinylpropan-2-one or 1-(4-chlorophenylsulfinyl)propan-2-one, aromatic aldehyde and ammonium acetate gives a series of 2,6-diary!-2,3-dihydro-1H-pyridin-4-one 6a,b. 4-Phenyl-2-amino-1,3-butadienes reacts with N-allyl benzaldimine through Diels-Alder reaction to afford 2,6-diphenyl-4-piperidinone derivative 7. Also, reactions of 2,6-diphenyl-piperdin-4-one are dis- cussed. The reactions of the latter compounds can be on nitrogen atom or carbonyl function group or methylene group adjacent to the carbonyl group. In addition, different applications of 2,6-diphenyl- piperidin-4-one are summarized.
引用
收藏
页码：125 / 135
页数：11
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