Chronic Antagonism of the Mineralocorticoid Receptor Ameliorates Hypertension and End Organ Damage in a Rodent Model of Salt-Sensitive Hypertension

被引：8
|
作者：
Zhou, Xiaoyan [1 ]
Crook, Martin F. [1 ]
Sharif-Rodriguez, Wanda [1 ]
Zhu, Yonghua [2 ]
Ruben, Zadok [3 ]
Pan, Yi [2 ]
Urosevic-Price, Olga [2 ]
Wang, Li [2 ]
Flattery, Amy M. [2 ]
Forrest, Gail [2 ]
Szeto, Daphne [2 ]
Zhao, Huawei [1 ]
Roy, Sophie [1 ]
Forrest, Michael J. [1 ]
机构：
[1] Merck & Co Inc, Merck Res Labs, Dept Cardiovasc Dis, Rahway, NJ 07065 USA
[2] Merck & Co Inc, Merck Res Labs, Dept Cent Pharmacol, Rahway, NJ 07065 USA
[3] Patoximed Consultants, Westfield, NJ USA
来源：
CLINICAL AND EXPERIMENTAL HYPERTENSION | 2011年 / 33卷 / 08期
关键词：
mineralocorticoid receptor antagonist; hypertension; end organ protection; eplerenone; Dahl salt-sensitive rats; SELECTIVE ALDOSTERONE BLOCKER; BLOOD-PRESSURE; RENIN-ACTIVITY; EPLERENONE; INJURY; HYPERTROPHY; FIBROSIS; DYSFUNCTION; ENALAPRIL; FAILURE;
D O I：
10.3109/10641963.2011.566956
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We investigated the effects of chronic mineralocorticoid receptor blockade with eplerenone on the development and progression of hypertension and end organ damage in Dahl salt-sensitive rats. Eplerenone significantly attenuated the progressive rise in systolic blood pressure (SBP) (204 +/- 3 vs. 179 +/- 3 mmHg, p < 0.05), reduced proteinuria (605.5 +/- 29.6 vs. 479.7 +/- 26.1 mg/24h, p < 0.05), improved injury scores of glomeruli, tubules, renal interstitium, and vasculature in Dahl salt-sensitive rats fed a high-salt diet. These results demonstrate that mineralocorticoid receptor antagonism provides target organ protection and attenuates the development of elevated blood pressure (BP) in a model of salt-sensitive hypertension.
引用
收藏
页码：538 / 547
页数：10
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