Chronic Antagonism of the Mineralocorticoid Receptor Ameliorates Hypertension and End Organ Damage in a Rodent Model of Salt-Sensitive Hypertension

被引：8

作者：

Zhou, Xiaoyan ^{[1
]}

Crook, Martin F. ^{[1
]}

Sharif-Rodriguez, Wanda ^{[1
]}

Zhu, Yonghua ^{[2
]}

Ruben, Zadok ^{[3
]}

Pan, Yi ^{[2
]}

Urosevic-Price, Olga ^{[2
]}

Wang, Li ^{[2
]}

Flattery, Amy M. ^{[2
]}

Forrest, Gail ^{[2
]}

Szeto, Daphne ^{[2
]}

Zhao, Huawei ^{[1
]}

Roy, Sophie ^{[1
]}

Forrest, Michael J. ^{[1
]}

机构：

[1] Merck & Co Inc, Merck Res Labs, Dept Cardiovasc Dis, Rahway, NJ 07065 USA

[2] Merck & Co Inc, Merck Res Labs, Dept Cent Pharmacol, Rahway, NJ 07065 USA

[3] Patoximed Consultants, Westfield, NJ USA

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION | 2011年 / 33卷 / 08期

关键词：

mineralocorticoid receptor antagonist; hypertension; end organ protection; eplerenone; Dahl salt-sensitive rats; SELECTIVE ALDOSTERONE BLOCKER; BLOOD-PRESSURE; RENIN-ACTIVITY; EPLERENONE; INJURY; HYPERTROPHY; FIBROSIS; DYSFUNCTION; ENALAPRIL; FAILURE;

D O I：

10.3109/10641963.2011.566956

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We investigated the effects of chronic mineralocorticoid receptor blockade with eplerenone on the development and progression of hypertension and end organ damage in Dahl salt-sensitive rats. Eplerenone significantly attenuated the progressive rise in systolic blood pressure (SBP) (204 +/- 3 vs. 179 +/- 3 mmHg, p < 0.05), reduced proteinuria (605.5 +/- 29.6 vs. 479.7 +/- 26.1 mg/24h, p < 0.05), improved injury scores of glomeruli, tubules, renal interstitium, and vasculature in Dahl salt-sensitive rats fed a high-salt diet. These results demonstrate that mineralocorticoid receptor antagonism provides target organ protection and attenuates the development of elevated blood pressure (BP) in a model of salt-sensitive hypertension.

引用

页码：538 / 547

页数：10

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