Cortical thickness across the cingulate gyrus in schizophrenia and its association to illness duration and memory performance

被引：7

作者：

Thielen, J-W ^{[1
]}

Mueller, B. W. ^{[1
,2
]}

Chang, D-, I ^{[3
]}

Krug, A. ^{[4
]}

Mehl, S. ^{[5
,6
]}

Rapp, A. ^{[7
]}

Walter, H. ^{[8
,9
,10
,11
]}

Winterer, G. ^{[12
]}

Vogeley, K. ^{[13
,14
]}

Klingberg, S. ^{[7
]}

Wagner, M. ^{[4
]}

Kircher, T. ^{[4
]}

机构：

[1] Univ Duisburg Essen, LVR Hosp Essen, Fac Med, Dept Psychiat & Psychotherapy, Duisburg, Germany

[2] Univ Wuppertal, Dept Psychol, Wuppertal, Germany

[3] Ruhr Univ Bochum, LWL Univ Hosp Bochum, Dept Psychiat, Bochum, Germany

[4] Univ Bonn, Dept Psychiat & Psychotherapy, Bonn, Germany

[5] Philipps Univ, Dept Psychiat & Psychotherapy, Marburg, Germany

[6] Philipps Univ, Ctr Mind Brain & Behav MCMBB, Marburg, Germany

[7] Univ Tubingen, Dept Psychiat & Psychotherapy, Tubingen, Germany

[8] Charite Univ Med Berlin, Div Mind & Brain Res, Dept Psychiat & Psychotherapy CCM, Berlin, Germany

[9] Free Univ Berlin, Berlin, Germany

[10] Humboldt Univ, Berlin, Germany

[11] Berlin Inst Hlth, Berlin, Germany

[12] Univ Berlin, Dept Psychiat & Psychotherapy, Berlin, Germany

[13] Univ Cologne, Dept Psychiat & Psychotherapy, Cologne, Germany

[14] Res Ctr Julich, Inst Neurosci & Med Cognit Neurosci INM 3, Julich, Germany

来源：

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | 2022年 / 272卷 / 07期

关键词：

Schizophrenia; Cingulate gyrus; Magnetic resonance imaging; Neuropsychological assessment; GRAY-MATTER ABNORMALITIES; POSTERIOR CINGULATE; CEREBRAL-CORTEX; DECISION-MAKING; WORKING-MEMORY; 1ST EPISODE; DIGIT SPAN; AGE; ONSET; MRI;

D O I：

10.1007/s00406-021-01369-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Schizophrenia has been associated with structural brain abnormalities and cognitive deficits that partly change during the course of illness. In the present study, cortical thickness in five subregions of the cingulate gyrus was assessed in 44 patients with schizophrenia-spectrum disorder and 47 control persons and related to illness duration and memory capacities. In the patients group, cortical thickness was increased in the posterior part of the cingulate gyrus and related to illness duration whereas cortical thickness was decreased in anterior parts unrelated to illness duration. In contrast, cortical thickness was related to episodic and working memory performance only in the anterior but not posterior parts of the cingulate gyrus. Our finding of a posterior cingulate increase may point to either increased parietal communication that is accompanied by augmented neural plasticity or to effects of altered neurodegenerative processes in schizophrenia.

引用

页码：1241 / 1251

页数：11

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