Synthesis and analgesic and anti-inflammatory activity of new pyridazinones

被引：0

作者：

Dogruer, DS

Sahin, MF ^{[1
]}

Küpeli, E

Yesilada, E

机构：

[1] Gazi Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06330 Ankara, Turkey

[2] Gazi Univ, Fac Pharm, Dept Pharmacognosy, TR-06330 Ankara, Turkey

来源：

TURKISH JOURNAL OF CHEMISTRY | 2003年 / 27卷 / 06期

关键词：

6-oxo-3,5-diphenylpyridazine; synthesis; spectral analysis; analgesic; anti-inflammatory;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new series of 2-(6-oxo-3,5-diphenyl-GH-pyridazin-1-yl)-acetamides and 3-[6-oxo-3,5-diphenyl-6H-pyridazin-1-yl)-propanamides were synthesized and evaluated in terms of their analgesic and anti-inflammatory activities. All compounds except for 7g were more potent than aspirin in a p-benzoquinone-induced writhing test at 100 mg/kg dose. Compounds 7b, 7c and 7e had the highest anti-inflammatory activity; compound 7e was the Most potent in terms of analgesic and anti-inflammatory activities and had no ulcerogenic side effects.

引用

页码：727 / 738

页数：12

共 21 条

[1] ANTIHYPERTENSIVE 5,6-DIARYLPYRIDAZIN-3-ONES [J].