Fatal outcome in a liver transplant recipient with COVID-19

被引:85
作者
Huang, Jiao-Feng [1 ]
Zheng, Kenneth I. [2 ]
George, Jacob [3 ,4 ]
Gao, Hai-Nv [5 ]
Wei, Ru-Nan [6 ]
Yan, Hua-Dong [7 ]
Zheng, Ming-Hua [2 ,8 ,9 ]
机构
[1] Fujian Med Univ, Affiliated Hosp 1, Dept Liver Res Ctr, Fuzhou, Peoples R China
[2] Wenzhou Med Univ, Affiliated Hosp 1, Dept Hepatol, NAFLD Res Ctr, Wenzhou, Peoples R China
[3] Westmead Hosp, Westmead Inst Med Res, Storr Liver Ctr, Sydney, NSW, Australia
[4] Univ Sydney, Sydney, NSW, Australia
[5] Zhejiang Shuren Univ, Shulan Int Med Coll, Shulan Hosp, Dept Infect Dis, Hangzhou, Peoples R China
[6] Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, State Key Lab Diag & Treatment Infect Dis, Natl Clin Res Ctr Infect Dis,Coll Med,Affiliated, Hangzhou, Peoples R China
[7] Univ Chinese Acad Sci, Key Lab Diag & Treatment Digest Syst Tumors Zheji, Dept Hepatol, Hwamei Hosp,Ningbo Hosp 2, Ningbo, Peoples R China
[8] Wenzhou Med Univ, Inst Hepatol, Wenzhou, Peoples R China
[9] Key Lab Diag & Treatment Dev Chron Liver Dis Zhej, Wenzhou, Peoples R China
基金
中国国家自然科学基金;
关键词
clinical research; practice; immunosuppressant; immunosuppression; immune modulation; infection and infectious agents; infection and infectious agents - viral; liver transplantation; hepatology;
D O I
10.1111/ajt.15909
中图分类号
R61 [外科手术学];
学科分类号
摘要
Liver injury is common in patients with COVID-19, but little is known about its clinical presentation and severity in the context of liver transplant. We describe a case of COVID-19 in a patient who underwent transplant 3 years ago for hepatocellular carcinoma. The patient came to clinic with symptoms of respiratory disease; pharyngeal swabs for severe acute respiratory syndrome coronavirus 2 were positive. His disease progressed rapidly from mild to critical illness and was complicated by several nosocomial infections and multiorgan failure. Despite multiple invasive procedures and rescue therapies, he died from the disease. The management of COVID-19 in the posttransplant setting presents complex challenges, emphasizing the importance of strict prevention strategies.
引用
收藏
页码:1907 / 1910
页数:4
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