Is the oncotype DX test useful in elderly breast cancer patients: a subgroup analysis of real-life Italian PONDx study

被引:5
作者
Barni, Sandro [1 ]
Cognetti, Francesco [2 ]
Petrelli, Fausto [1 ]
机构
[1] ASST Bergamo Ovest, Dept Med Sci, Oncol Unit, Piazzale Osped 1, I-24047 Treviglio, Italy
[2] Univ Roma La Sapienza, Dipartimento Med Clin & Mol, Rome, Italy
关键词
Breast cancer; Oncotype DX; Adjuvant chemotherapy; Older patients; Real life; DECISION-MAKING; OLDER PATIENTS; EARLY-STAGE; CHEMOTHERAPY; IMPACT; WOMEN;
D O I
10.1007/s10549-021-06464-5
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Introduction The 21-gene Oncotype DX Breast Recurrence Score (R) test, (Genomic Health, Redwood City CA) has not been formally evaluated in an older cohort with estrogen receptor (ER)-positive breast cancer (BC) in term of physicians' treatment decisions. We determine the utility of Recurrence Score (R) (RS) result on adjuvant therapy prescription in elderly patients with resected early BC. Material and methods PONDx was a multicenter, prospective, observational study, and which investigated the real-life use of the Oncotype DX (R) test by physicians treating early BC patients in clinical practice. Results Data from the elderly extracted from 1724 BC patients who underwent Oncotype DX testing were available from 27 reference centers located in 6 regions of Italy (Lombardia, Lazio, Emilia Romagna, Campania, Abruzzo, and Marche). A total of 230 patients (13% of the total population) aged > 70 years were analyzed. The study primarily evaluated the impact of the Oncotype DX test on adjuvant treatment decisions. Physicians chosen chemotherapy plus endocrine therapy in 36% of elderly patients and 46% of those 50-70 years before the Oncotype DX test. After knowing the RS data, these rates fell to 23 and 33% (38 and 28% relative reduction, respectively). Conclusions 21-gene test may be helpful even in a relatively low-risk group as elderly patients and may avoid the toxicity of adjuvant chemotherapy in a significant amount. If the Oncotype DX test is currently adopted on a large scale among the elderly and may impact the general prognosis of elderly BC patients, it is challenging and still unproven.
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收藏
页码:477 / 480
页数:4
相关论文
共 10 条
[1]   Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100 000 women in 123 randomised trials [J].
Albain, K. ;
Anderson, S. ;
Arriagada, R. ;
Barlow, W. ;
Bergh, J. ;
Bliss, J. ;
Buyse, M. ;
Cameron, D. ;
Carrasco, E. ;
Clarke, M. ;
Correa, C. ;
Coates, A. ;
Collins, R. ;
Costantino, J. ;
Cutter, D. ;
Cuzick, J. ;
Darby, S. ;
Davidson, N. ;
Davies, C. ;
Davies, K. ;
Delmestri, A. ;
Di Leo, A. ;
Dowsett, M. ;
Elphinstone, P. ;
Evans, V. ;
Ewertz, M. ;
Gelber, R. ;
Gettins, L. ;
Geyer, C. ;
Goldhirsch, A. ;
Godwin, J. ;
Gray, R. ;
Gregory, C. ;
Hayes, D. ;
Hill, C. ;
Ingle, J. ;
Jakesz, R. ;
James, S. ;
Kaufmann, M. ;
Kerr, A. ;
MacKinnon, E. ;
McGale, P. ;
McHugh, T. ;
Norton, L. ;
Ohashi, Y. ;
Paik, S. ;
Pan, H. C. ;
Perez, E. ;
Peto, R. ;
Piccart, M. .
LANCET, 2012, 379 (9814) :432-444
[2]   Pooled analysis of prospective European studies assessing the impact of using the 21-gene Recurrence Score assay on clinical decision making in women with oestrogen receptor-positive, human epidermal growth factor receptor 2enegative early-stage breast cancer [J].
Albanell, Joan ;
Svedman, Christer ;
Gligorov, Joseph ;
Holt, Simon D. H. ;
Bertelli, Gianfilippo ;
Blohmer, Jens-Uwe ;
Rouzier, Roman ;
Lluch, Ana ;
Eiermann, Wolfgang .
EUROPEAN JOURNAL OF CANCER, 2016, 66 :104-113
[3]   Updated recommendations regarding the management of older patients with breast cancer: a joint paper from the European Society of Breast Cancer Specialists (EUSOMA) and the International Society of Geriatric Oncology (SIOG) [J].
Biganzoli, Laura ;
Battisti, Nicole Matteo Luca ;
Wildiers, Hans ;
McCartney, Amelia ;
Colloca, Giuseppe ;
Kunkler, Ian H. ;
Cardoso, Maria-Joao ;
Cheung, Kwok-Leung ;
de Glas, Nienke Aafke ;
Trimboli, Rubina M. ;
Korc-Grodzicki, Beatriz ;
Soto-Perez-de-Celis, Enrique ;
Ponti, Antonio ;
Tsang, Janice ;
Marotti, Lorenza ;
Benn, Karen ;
Aapro, Matti S. ;
Brain, Etienne G. C. .
LANCET ONCOLOGY, 2021, 22 (07) :E327-E340
[4]   PONDx: real-life utilization and decision impact of the 21-gene assay on clinical practice in Italy [J].
Cognetti, Francesco ;
Masetti, Riccardo ;
Fabi, Alessandra ;
Bianchi, Giulia ;
Santini, Donatella ;
Rognone, Alessia ;
Catania, Giovanna ;
Angelucci, Domenico ;
Naso, Giuseppe ;
Giuliano, Mario ;
Vassalli, Lucia ;
Vici, Patrizia ;
Scognamiglio, Giovanni ;
Generali, Daniele ;
Zambelli, Alberto ;
Colleoni, Marco ;
Tinterri, Corrado ;
Scanzi, Francesco ;
Vigna, Leonardo ;
Scavina, Paola ;
Gamucci, Teresa ;
Marrazzo, Emilia ;
Scinto, Angelo Fedele ;
Berardi, Rossana ;
Fabbri, Maria Agnese ;
Pinotti, Graziella ;
Franco, Daniela ;
Terribile, Daniela Andreina ;
Tonini, Giuseppe ;
Cianniello, Daniela ;
Barni, Sandro .
NPJ BREAST CANCER, 2021, 7 (01)
[5]   Validity of Adjuvant! Online program in older patients with breast cancer: a population-based study [J].
de Glas, Nienke A. ;
van de Water, Willemien ;
Engelhardt, Ellen G. ;
Bastiaannet, Esther ;
de Craen, Anton J. M. ;
Kroep, Judith R. ;
Putter, Hein ;
Stiggelbout, Anne M. ;
Weijl, Nir I. ;
van de Velde, Cornelis J. H. ;
Portielje, Johanneke E. A. ;
Liefers, Gerrit-Jan .
LANCET ONCOLOGY, 2014, 15 (07) :722-729
[6]   21-gene recurrence score testing in the older population with estrogen receptor-positive breast cancer [J].
Kizy, Scott ;
Altman, Ariella M. ;
Marmor, Schelomo ;
Denbo, Jason W. ;
Jensen, Eric H. ;
Tuttle, Todd M. ;
Hui, Jane Yuet Ching .
JOURNAL OF GERIATRIC ONCOLOGY, 2019, 10 (02) :322-329
[7]   Treatment Strategies in Octogenarians with Early-Stage, High-Risk Breast Cancer [J].
Mamtani, Anita ;
Gonzalez, Julie J. ;
Neo, Dayna T. ;
Friedman, Robb S. ;
Recht, Abram ;
Hacker, Michele R. ;
Sharma, Ranjna .
ANNALS OF SURGICAL ONCOLOGY, 2018, 25 (06) :1495-1501
[8]   Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer [J].
Sparano, J. A. ;
Gray, R. J. ;
Makower, D. F. ;
Pritchard, K. I. ;
Albain, K. S. ;
Hayes, D. F. ;
Geyer, C. E., Jr. ;
Dees, E. C. ;
Goetz, M. P. ;
Olson, J. A., Jr. ;
Lively, T. ;
Badve, S. S. ;
Saphner, T. J. ;
Wagner, L. I. ;
Whelan, T. J. ;
Ellis, M. J. ;
Paik, S. ;
Wood, W. C. ;
Ravdin, P. M. ;
Keane, M. M. ;
Moreno, H. L. Gomez ;
Reddy, P. S. ;
Goggins, T. F. ;
Mayer, I. A. ;
Brufsky, A. M. ;
Toppmeyer, D. L. ;
Kaklamani, V. G. ;
Berenberg, J. L. ;
Abrams, J. ;
Sledge, G. W., Jr. .
NEW ENGLAND JOURNAL OF MEDICINE, 2018, 379 (02) :111-121
[9]   Impact of 21-gene recurrence score testing on adjuvant chemotherapy decision making in older patients with breast cancer [J].
Zeng, Yufei ;
Gao, Weiqi ;
Lin, Lin ;
Chen, Xiaosong ;
Shen, Kunwei .
JOURNAL OF GERIATRIC ONCOLOGY, 2020, 11 (05) :843-849
[10]   Chemotherapy and 21-gene recurrence score testing for older breast cancer patients: A competing-risks analysis [J].
Zhou, Ping ;
Zhang, Wen-Wen ;
Bao, Yong ;
Wang, Jun ;
Lian, Chen-Lu ;
He, Zhen-Yu ;
Wu, San-Gang .
BREAST, 2020, 54 :319-327