Adipogenic action of vanadium: a new dimension in treating diabetes

被引：16

作者：

Shukla, Ruchi ^{[1
]}

Bhonde, Ramesh R. ^{[1
]}

机构：

[1] Univ Poona, Natl Ctr Cell Sci, Tissue Engn & Banking Lab, Pune 411007, Maharashtra, India

来源：

BIOMETALS | 2008年 / 21卷 / 02期

关键词：

vanadium; 3T3-L1; cells; adipogenesis; CREB activation;

D O I：

10.1007/s10534-007-9109-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vanadium is a well known anti-diabetic agent which mimics most of the actions of insulin on mature adipocytes. We report here the effect of vanadium on proliferation and differentiation of 3T3-L1 preadipocytes. Like insulin, vanadium treatment leads to increased proliferation as evidenced by H(3)thymidine uptake studies and differentiation of 3T3-L1 cells into adipocytes as evidenced by oil-red-O staining. Adipogenic potential of vanadium can be attributed to CREB activation, as documented by phospho-CREB antibody staining. This adipogenic potential is of significance in an in vivo scenario as the new adipocytes are likely to be insulin sensitive as against resistant existing mature adipocytes and thus indirectly may help in reduction of insulin resistance. Till today decrease in insulin resistance by vanadium treatment has been mainly attributed to its potential to inhibit PTP-1B, however the present study opens a new dimension in vanadium treatment for diabetes due to its novel role in adipogenesis.

引用

页码：205 / 210

页数：6

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