Genomic Profiling of Mycobacterium tuberculosis Strains, Myanmar

被引：10

作者：

Aung, Htin Lin ^{[1
]}

Nyunt, Wint Wint ^{[2
]}

Fong, Yang ^{[3
]}

Biggs, Patrick J. ^{[3
]}

Winkworth, Richard C. ^{[3
]}

Lockhart, Peter J. ^{[3
]}

Yeo, Tsin Wen ^{[4
]}

Hill, Philip C. ^{[1
]}

Cook, Gregory M. ^{[1
]}

Aung, Si Thu ^{[5
]}

机构：

[1] Univ Otago, Dunedin, New Zealand

[2] Minist Hlth & Sports, Yangon, Myanmar

[3] Massey Univ, Palmerston North, New Zealand

[4] Nanyang Technol Univ, Singapore, Singapore

[5] Minist Hlth & Sports, Naypyitaw, Myanmar

来源：

EMERGING INFECTIOUS DISEASES | 2021年 / 27卷 / 11期

关键词：

DRUG-RESISTANT TUBERCULOSIS; SUSCEPTIBILITY; CHINA;

D O I：

10.3201/eid2711.210726

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Multidrug resistance is a major threat to global elimination of tuberculosis (TB). We performed phenotypic drug-susceptibility testing and whole-genome sequencing for 309 isolates from 342 consecutive patients who were given a diagnosis of TB in Yangon, Myanmar, during July 2016. June 2018. We identified isolates by using the GeneXpert platform to evaluate drug-resistance profiles. A total of 191 (62%) of 309 isolates had rifampin resistance; 168 (88%) of these rifampin-resistant isolates were not genomically related, indicating the repeated emergence of resistance in the population, rather than extensive local transmission. We did not detect resistance mutations to new oral drugs, including bedaquiline and pretomanid. The current GeneXpert MTB/RIF system needs to be modified by using the newly launched Xpert MTB/XDR cartridge or line-probe assay. Introducing new oral drugs to replace those currently used in treatment regimens for multidrug-resistant TB will also be useful for treating TB in Myanmar.

引用

页码：2847 / 2855

页数：9

共 32 条

[1] Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing [J].

Allix-Beguec, Caroline ;

Arandjelovic, Irena ;

Bi, Lijun ;

Beckert, Patrick ;

Bonnet, Maryline ;

Bradley, Phelim ;

Cabibbe, Andrea M. ;

Cancino-Munoz, Irving ;

Caulfield, Mark J. ;

Chaiprasert, Angkana ;

Cirillo, Daniela M. ;

Clifton, David ;

Comas, Inaki ;

Crook, Derrick W. ;

De Filippo, Maria R. ;

de Neeling, Han ;

Diel, Roland ;

Drobniewski, Francis A. ;

Faksri, Kiatichai ;

Farhat, Maha R. ;

Fleming, Joy ;

Fowler, Philip ;

Fowler, Tom A. ;

Gao, Qian ;

Gardy, Jennifer ;

Gascoyne-Binzi, Deborah ;

Gibertoni-Cruz, Ana-Luiza ;

Gil-Brusola, Ana ;

Golubchik, Tanya ;

Gonzalo, Ximena ;

Grandjean, Louis ;

He, Guangxue ;

Guthrie, Jennifer L. ;

Hoosdally, Sarah ;

Hunt, Martin ;

Iqbal, Zamin ;

Ismail, Nazir ;

Johnston, James ;

Khanzada, Faisal M. ;

Khor, Chiea C. ;

Kohl, Thomas A. ;

Kong, Clare ;

Lipworth, Sam ;

Liu, Qingyun ;

Maphalala, Gugu ;

Martinez, Elena ;

Mathys, Vanessa ;

Merker, Matthias ;

Miotto, Paolo ;

Mistry, Nerges .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 379 (15) :1403-1415

[2] Extensively drug-resistant tuberculosis in South Africa: genomic evidence supporting transmission in communities [J].

Auld, Sara C. ;

Shah, N. Sarita ;

Mathema, Barun ;

Brown, Tyler S. ;

Ismail, Nazir ;

Omar, Shaheed Vally ;

Brust, James C. M. ;

Nelson, Kristin N. ;

Allana, Salim ;

Campbell, Angela ;

Mlisana, Koleka ;

Moodley, Pravi ;

Gandhi, Neel R. .

EUROPEAN RESPIRATORY JOURNAL, 2018, 52 (04)

[3] Tackling tuberculosis in the indigenous people of New Zealand [J].

Aung, Htin Lin ;

Devine, Thomas J. ;

Mulholland, Claire V. ;

Arcus, Vickery L. ;

Cook, Gregory M. .

LANCET PUBLIC HEALTH, 2019, 4 (10) :E496-E496

[4] Acquired Resistance to Antituberculosis Drugs [J].

Aung, Htin Lin ;

Nyunt, Wint Wint ;

Fong, Yang ;

Russell, Bruce ;

Cook, Gregory M. ;

Aung, Si Thu .

EMERGING INFECTIOUS DISEASES, 2018, 24 (11) :2134-2134

[5] First 2 Extensively Drug-Resistant Tuberculosis Cases From Myanmar Treated With Bedaquiline [J].

Aung, Htin Lin ;

Nyunt, Wint Wint ;

Fong, Yang ;

Cook, Gregory M. ;

Aung, Si Thu .

CLINICAL INFECTIOUS DISEASES, 2017, 65 (03) :531-532

[6] Whole-genome sequencing of multidrug-resistant Mycobacterium tuberculosis isolates from Myanmar [J].

Aung, Htin Lin ;

Tun, Thanda ;

Moradigaravand, Danesh ;

Koser, Claudio U. ;

Nyunt, Wint Wint ;

Aung, Si Thu ;

Lwin, Thandar ;

Thinn, Kyi Kyi ;

Crump, John A. ;

Parkhill, Julian ;

Peacock, Sharon J. ;

Cook, Gregory M. ;

Hill, Philip C. .

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, 2016, 6 :113-117

[7]

Cepheid, NEW RAP MOL TEST TUB

[8] Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences [J].

Coll, Francesc ;

McNerney, Ruth ;

Preston, Mark D. ;

Guerra-Assuncao, Jose Afonso ;

Warry, Andrew ;

Hill-Cawthorne, Grant ;

Mallard, Kim ;

Nair, Mridul ;

Miranda, Anabela ;

Alves, Adriana ;

Perdigao, Joao ;

Viveiros, Miguel ;

Portugal, Isabel ;

Hasan, Zahra ;

Hasan, Rumina ;

Glynn, Judith R. ;

Martin, Nigel ;

Pain, Arnab ;

Clark, Taane G. .

GENOME MEDICINE, 2015, 7

[9] Treatment of Highly Drug-Resistant Pulmonary Tuberculosis [J].

Conradie, Francesca ;

Diacon, Andreas H. ;

Ngubane, Nosipho ;

Howell, Pauline ;

Everitt, Daniel ;

Crook, Angela M. ;

Mendel, Carl M. ;

Egizi, Erica ;

Moreira, Joanna ;

Timm, Juliano ;

McHugh, Timothy D. ;

Wills, Genevieve H. ;

Bateson, Anna ;

Hunt, Robert ;

Van Niekerk, Christo ;

Li, Mengchun ;

Olugbosi, Morounfolu ;

Spigelman, Melvin .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (10) :893-902

[10] Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data [J].

Dean, Anna S. ;

Zignol, Matteo ;

Cabibbe, Andrea Maurizio ;

Falzon, Dennis ;

Glaziou, Philippe ;

Cirillo, Daniela Maria ;

Koser, Claudio U. ;

Gonzalez-Angulo, Lice Y. ;

Tosas-Auget, Olga ;

Ismail, Nazir ;

Tahseen, Sabira ;

Ama, Maria Cecilia G. ;

Skrahina, Alena ;

Alikhanova, Natavan ;

Kamal, S. M. Mostofa ;

Floyd, Katherine .

PLOS MEDICINE, 2020, 17 (01)

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