A clinical signature predicting the malignant transformation of inflammatory myofibroblastic tumor in the head and neck

被引：5

作者：

Peng, Cangbang ^{[1
]}

Chen, Ming Tao ^{[2
,3
,4
]}

Liu, Zheqi ^{[2
,3
,4
]}

Guo, Yibo ^{[2
,3
,4
]}

Zhang, Yu ^{[2
,3
,4
]}

Ji, Tong ^{[2
,3
,4
]}

机构：

[1] Kunming Med Univ, Hosp Stomatol, Kunming, Yunnan, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 9, Dept Oral & Maxillofacial Head & Neck Oncol, Shanghai, Peoples R China

[3] Shanghai Jiao Tong Univ, Coll Stomatol, Shanghai, Peoples R China

[4] Natl Ctr Stomatol, Shanghai, Peoples R China

来源：

LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY | 2022年 / 7卷 / 01期

基金：

中国国家自然科学基金;

关键词：

head neck; inflammatory myofibroblastic tumor; malignant transformation; postoperative radiotherapy; predicative model; LYMPHOCYTE RATIO; SARCOMA;

D O I：

10.1002/lio2.731

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background Inflammatory myofibroblastic tumors in the head and neck (HNIMTs) sometimes show aggressive clinical features and can be diagnosed as HNIMT with malignant transformation. Methods The clinicopathological features of 45 HNIMTs with or without malignant transformation were retrospectively investigated. Logistic regression and receiver operating characteristic analysis were used to establish the predictive model. Results HNIMT with malignant transformation was associated with worse prognosis. HNIMT with a tumor size of >4.4 cm, tumors located in the maxillary sinus, or a preoperative neutrophil-to-lymphocyte ratio (NLR) greater than 1.958 were associated with higher chance of malignant transformation, with an AUC value of 0.9189. Postoperative radiotherapy could benefit HNIMT patients with high risk of malignant transformation. Conclusions HNIMT patients with a tumor size of >4.4 cm, tumors located in the maxillary sinus, and a preoperative NLR over 1.958 were associated with a higher risk of malignant transformation. These patients can benefit from postoperative radiotherapy.

引用

页码：145 / 152

页数：8

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