Disease modification is not all - we need symptomatic therapies for Alzheimer disease

被引:7
作者
Cummings, Jeffrey [1 ]
机构
[1] Univ Nevada, Sch Integrated Hlth Sci, Dept Brain Hlth, Chambers Grundy Ctr Transformat Neurosci, Las Vegas, NV 89154 USA
关键词
APATHY;
D O I
10.1038/s41582-021-00591-9
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
A new study found methylphenidate to be effective in treating apathy in individuals with Alzheimer disease. At a time when the recent aducanumab approval is focusing attention on the promise of disease-modifying therapies, the new findings highlight the importance of developing better symptomatic treatment options for individuals with psychiatric disorders of Alzheimer disease.
引用
收藏
页码:3 / 4
页数:2
相关论文
共 9 条
[1]  
Cummings J., 2021, ALZHEIMERS DEMENT, V7, pE12179
[2]   Neuropathologic correlates of apathy in Alzheimer's disease [J].
Marshall, GA ;
Fairbanks, LA ;
Tekin, S ;
Vinters, HV ;
Cummings, JL .
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2006, 21 (03) :144-147
[3]   Diagnostic criteria for apathy in neurocognitive disorders [J].
Miller, David S. ;
Robert, Philippe ;
Ereshefsky, Larry ;
Adler, Lawrence ;
Bateman, Daniel ;
Cummings, Jeff ;
DeKosky, Steven T. ;
Fischer, Corinne E. ;
Husain, Masud ;
Ismail, Zahinoor ;
Jaeger, Judith ;
Lerner, Alan J. ;
Li, Abby ;
Lyketsos, Constantine G. ;
Manera, Valeria ;
Mintzer, Jacobo ;
Moebius, Hans J. ;
Mortby, Moyra ;
Meulien, Didier ;
Pollentier, Stephane ;
Porsteinsson, Anton ;
Rasmussen, Jill ;
Rosenberg, Paul B. ;
Ruthirakuhan, Myuri T. ;
Sano, Mary ;
Sarracini, Carla Zucchero ;
Lanctot, Krista L. .
ALZHEIMERS & DEMENTIA, 2021, 17 (12) :1892-1904
[4]   Effect of Methylphenidate on Apathy in Patients With Alzheimer Disease The ADMET 2 Randomized Clinical Trial [J].
Mintzer, Jacobo ;
Lanctot, Krista L. ;
Scherer, Roberta W. ;
Rosenberg, Paul B. ;
Herrmann, Nathan ;
van Dyck, Christopher H. ;
Padala, Prasad R. ;
Brawman-Mintzer, Olga ;
Porsteinsson, Anton P. ;
Lerner, Alan J. ;
Craft, Suzanne ;
Levey, Allan, I ;
Burke, William ;
Perin, Jamie ;
Shade, David .
JAMA NEUROLOGY, 2021, 78 (11) :1324-1332
[5]   Predictors of Family Caregiver Ratings of Patient Quality of Life in Alzheimer Disease: Cross-Sectional Results from the Canadian Alzheimer's Disease Quality of Life Study [J].
Naglie, Gary ;
Hogan, David B. ;
Krahn, Murray ;
Black, Sandra E. ;
Beattie, B. Lynn ;
Patterson, Christopher ;
MacKnight, Chris ;
Freedman, Morris ;
Borrie, Michael ;
Byszewski, Anna ;
Bergman, Howard ;
Streiner, David ;
Irvine, Jane ;
Ritvo, Paul ;
Comrie, Janna ;
Kowgier, Matthew ;
Tomlinson, George .
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2011, 19 (10) :891-901
[6]   Controversy and Progress in Alzheimer's Disease - FDA Approval of Aducanumab [J].
Rabinovici, Gil D. .
NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (09) :771-774
[7]   Safety and Efficacy of Methylphenidate for Apathy in Alzheimer's Disease: A Randomized, Placebo-Controlled Trial [J].
Rosenberg, Paul B. ;
Lanctot, Krista L. ;
Drye, Lea T. ;
Herrmann, Nathan ;
Scherer, Roberta W. ;
Bachman, David L. ;
Mintzer, Jacobo E. .
JOURNAL OF CLINICAL PSYCHIATRY, 2013, 74 (08) :810-816
[8]   Trial of Pimavanserin in Dementia-Related Psychosis [J].
Tariot, Pierre N. ;
Cummings, Jeffrey L. ;
Soto-Martin, Maria E. ;
Ballard, Clive ;
Erten-Lyons, Deniz ;
Sultzer, David L. ;
Devanand, Davangere P. ;
Weintraub, Daniel ;
McEvoy, Bradley ;
Youakim, James M. ;
Stankovic, Srdjan ;
Foff, Erin P. .
NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (04) :309-319
[9]   Cognitive Effects of Atypical Antipsychotic Medications in Patients With Alzheimer's Disease: Outcomes From CATIE-AD [J].
Vigen, Cheryl L. P. ;
Mack, Wendy J. ;
Keefe, Richard S. E. ;
Sano, Mary ;
Sultzer, David L. ;
Stroup, T. Scott ;
Dagerman, Karen S. ;
Hsiao, John K. ;
Lebowitz, Barry D. ;
Lyketsos, Constantine G. ;
Tariot, Pierre N. ;
Zheng, Ling ;
Schneider, Lon S. .
AMERICAN JOURNAL OF PSYCHIATRY, 2011, 168 (08) :831-839