Determination of Rosiglitazone by Direct Analysis in Real-Time Mass Spectrometry

被引：2

作者：

Liu, Wenlong ^{[1
]}

He, Yangfang ^{[2
]}

Zhang, Hongmei ^{[3
]}

Su, Rui ^{[1
]}

Xiu, Yang ^{[1
]}

Liu, Shuying ^{[1
]}

机构：

[1] Changchun Univ Chinese Med, Jilin Ginseng Acad, Changchun 130117, Jilin, Peoples R China

[2] Jilin Univ, Hosp 2, Dept Endocrinol, Changchun, Jilin, Peoples R China

[3] Jilin Univ, Part Hosp 2 1, Dept Pharm, Changchun, Jilin, Peoples R China

来源：

ANALYTICAL LETTERS | 2017年 / 50卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Direct analysis in real-time mass spectrometry; internal standard; pioglitazone; quantitative analysis; rosiglitazone; PERFORMANCE LIQUID-CHROMATOGRAPHY; SOLID-PHASE MICROEXTRACTION; ELECTROSPRAY IONIZATION; DIETARY-SUPPLEMENTS; HERBAL REMEDIES; ADULTERANTS; SAMPLES; MS;

D O I：

10.1080/00032719.2016.1248245

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The determination of rosiglitazone in dietary supplements by direct analysis in real-time mass spectrometry normally provides low repeatability. The [M+H](+) signal sharply decreased in the presence of strong-base and weak-acid ionic compounds because rosiglitazone decomposition occurred due to the hydrolysis of strong-base and weak-acid anions. The repeatability was improved and the influence of ionic compounds was minimized by the use of pioglitazone as an internal standard. Orbitrap mass spectrometry was used to provide high resolution in which isotopic interferences from M + 1 of pioglitazone upon M of rosiglitazone were eliminated. This approach was used to determine rosiglitazone in tablet and dietary supplements in 1 min per sample.

引用

页码：1721 / 1729

页数：9

共 20 条

[1] Applications of Solid-Phase Microextraction for the Analysis of Pesticide Residues in Fruits and Vegetables: A Review [J].

Abdulra'uf, Lukman Bola ;

Chai, Mee Kin ;

Tan, Guan Huat .

JOURNAL OF AOAC INTERNATIONAL, 2012, 95 (05) :1272-1290

[2] High-performance liquid chromatography coupled to direct analysis in real time mass spectrometry: Investigations on gradient elution and influence of complex matrices on signal intensities [J].

Beissmann, Susanne ;

Buchberger, Wolfgang ;

Hertsens, Robert ;

Klampfl, Christian W. .

JOURNAL OF CHROMATOGRAPHY A, 2011, 1218 (31) :5180-5186

[3] Application of LC-ESI-MS-MS for detection of synthetic adulterants in herbal remedies [J].

Bogusz, MJ ;

Hassan, H ;

Ai-Enazi, E ;

Ibrahim, Z ;

Al-Tufail, M .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2006, 41 (02) :554-564

[4] Online Coupling of Capillary Electrophoresis with Direct Analysis in Real Time Mass Spectrometry [J].

Chang, Cuilan ;

Xu, Gege ;

Bai, Yu ;

Zhang, Chengsen ;

Li, Xianjiang ;

Li, Min ;

Liu, Yi ;

Liu, Huwei .

ANALYTICAL CHEMISTRY, 2013, 85 (01) :170-176

[5] Normal phase LC coupled with direct analysis in real time MS for the chiral analysis of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and jasmonic acid [J].

Chang, Cuilan ;

Zhou, Zhigui ;

Yang, Youyou ;

Han, Yehua ;

Bai, Yu ;

Zhao, Meiping ;

Liu, Huwei .

ELECTROPHORESIS, 2012, 33 (22) :3387-3393

[6] Letter: Characterization of volatile and semi-volatile compounds in green and fermented leaves of Bergenia crassifolia L. by gas chromatography-mass spectrometry and ID-CUBE direct analysis in real time-high resolution mass spectrometry [J].

Chernetsova, Elena S. ;

Shikov, Alexander N. ;

Crawford, Elizabeth A. ;

Grashorn, Sebastian ;

Laakso, I. ;

Pozharitskaya, Olga N. ;

Makarov, Valery G. ;

Hiltunen, Raimo ;

Galambosi, Bertalan ;

Morlock, Gertrud E. .

EUROPEAN JOURNAL OF MASS SPECTROMETRY, 2014, 20 (02) :199-205

[7] HIGH-SPEED LIQUID-CHROMATOGRAPHY TANDEM MASS-SPECTROMETRY FOR THE DETERMINATION OF DRUGS IN BIOLOGICAL SAMPLES [J].

COVEY, TR ;

LEE, ED ;

HENION, JD .

ANALYTICAL CHEMISTRY, 1986, 58 (12) :2453-2460

[8] Investigations on the Coupling of High-Performance Liquid Chromatography to Direct Analysis in Real Time Mass Spectrometry [J].

Eberherr, Walter ;

Buchberger, Wolfgang ;

Hertsens, Robert ;

Klampfl, Christian W. .

ANALYTICAL CHEMISTRY, 2010, 82 (13) :5792-5796

[9] ELECTROSPRAY IONIZATION FOR MASS-SPECTROMETRY OF LARGE BIOMOLECULES [J].

FENN, JB ;

MANN, M ;

MENG, CK ;

WONG, SF ;

WHITEHOUSE, CM .

SCIENCE, 1989, 246 (4926) :64-71

[10] Direct Analysis in Real Time-Mass Spectrometry for the Rapid Detection of Metabolites of Aconite Alkaloids in Intestinal Bacteria [J].

Li, Xue ;

Hou, Guangyue ;

Xing, Junpeng ;

Song, Fengrui ;

Liu, Zhiqiang ;

Liu, Shuying .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2014, 25 (12) :2181-2184

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