Drugging Wnt signalling in cancer

被引：176
作者：
Polakis, Paul [1 ]
机构：
[1] Genentech Inc, Dept Mol Oncol, San Francisco, CA 94080 USA
来源：
EMBO JOURNAL | 2012年 / 31卷 / 12期
关键词：
cancer; drugs; Wnt; SMALL-MOLECULE INHIBITORS; WNT/BETA-CATENIN PATHWAY; CELLS IN-VITRO; BETA-CATENIN; STEM-CELLS; COLORECTAL-CANCER; COLON-CANCER; CRYSTAL-STRUCTURE; SMALL-INTESTINE; BREAST-CANCER;
D O I：
10.1038/emboj.2012.126
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Aberrant regulation of the Wnt signalling pathway has emerged as a prevalent theme in cancer biology. This chapter summarizes the research that provides a proof of concept for inhibiting Wnt signalling in cancer, the potential means by which this could be achieved, and some recent advances towards this goal. A brief discussion of molecular diagnostics and possible safety concerns is also provided. The EMBO Journal (2012) 31, 2737-2746. doi:10.1038/emboj.2012.126; Published online 22 May 2012
引用
收藏
页码：2737 / 2746
页数：10
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